Troisi J, Mikelson C, Richards S, Symes S, Adair D, Zullo F, Guida M
Dipartimento di ostetricia e ginecologia, Università degli studi di Salerno, Italy.
Department of Biological and Environmental Sciences, University of Tennessee-Chattanooga, Chattanooga, TN, USA.
Placenta. 2014 Nov;35(11):947-52. doi: 10.1016/j.placenta.2014.08.091. Epub 2014 Sep 6.
Bisphenol A (BPA) is a weakly estrogenic compound that has been detected in a wide variety of food products and biological matrices (saliva, blood, urine, etc). Despite the potential risk of human exposure to BPA, little information exists concerning maternal and fetal exposure to BPA during pregnancy. The aim of this study is to evaluate the correlation between placental BPA concentration, infant birth weight and calculated birth weight centile, and several other maternal and infant parameters.
Placental sample were collected from 200 subjects. BPA levels were measured by isotope dilution GC-MS. Additional maternal and infant data were gathered from medical charts and were potential correlates with placental BPA levels.
Placental BPA concentrations ranged from 4.4 ng/g to 273.9 ng/g in oven-dried tissue (average 103.4 ± 61.8 ng/g). There was a significant negative correlation between calculated birth weight centile and levels of placental BPA (p < 0.05). Low birth weight and small for gestational age infants also had significantly greater placental BPA concentrations as compared to normal weight infants and average/large for gestational age infants. Infants born to African American mothers also had greater placental BPA concentrations as compared to infants born to Hispanic mothers.
Placental BPA concentrations are correlated with the growth potential of the fetus and may play a role in reduced fetal growth.
双酚A（BPA）是一种弱雌激素化合物，已在多种食品和生物基质（唾液、血液、尿液等）中被检测到。尽管人类接触双酚A存在潜在风险，但关于孕期母婴接触双酚A的信息却很少。本研究的目的是评估胎盘双酚A浓度、婴儿出生体重和计算得出的出生体重百分位数以及其他一些母婴参数之间的相关性。
从200名受试者中收集胎盘样本。采用同位素稀释气相色谱 - 质谱法测量双酚A水平。从病历中收集额外的母婴数据，并将其作为与胎盘双酚A水平可能存在的相关性因素。
烘干组织中胎盘双酚A浓度范围为4.4纳克/克至273.9纳克/克（平均103.4±61.8纳克/克）。计算得出的出生体重百分位数与胎盘双酚A水平之间存在显著负相关（p<0.05）。与正常体重婴儿以及适于胎龄平均/较大婴儿相比，低出生体重和小于胎龄婴儿的胎盘双酚A浓度也显著更高。非裔美国母亲所生婴儿的胎盘双酚A浓度也高于西班牙裔母亲所生婴儿。
胎盘双酚A浓度与胎儿的生长潜力相关，可能在胎儿生长受限中起作用。
