Institute for Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.
Exp Brain Res. 2012 Sep;221(3):329-35. doi: 10.1007/s00221-012-3175-8. Epub 2012 Jul 22.
The sleep-wake cycle is a major determinant of locomotor activity in humans, and the neural and physiological processes necessary for optimum postural control may be impaired by an extension of the wake period into habitual sleep time. There is growing evidence for such a contribution from sleep-related factors, but great inconsistency in the methods used to assess this contribution, particularly in control for circadian phase position. Postural control was assessed at hourly intervals across 14 h of extended wake in nine young adult participants. Force plate parameters of medio-lateral and anterior-posterior sway, centre of pressure (CoP) trace length, area, and velocity were assessed with eyes open and eyes closed over 3-min periods. A standard measure of psychomotor vigilance was assessed concurrently under constant routine conditions. After controlling for individual differences in circadian phase position, a significant effect of extended wake was found for anterior-posterior sway and for psychomotor vigilance. These data suggest that extended wake may increase the risk of a fall or other consequences of impaired postural control.
睡眠-觉醒周期是人类运动活动的主要决定因素，而对于最佳姿势控制所需的神经和生理过程可能会因将觉醒期延长到习惯性睡眠时间而受损。越来越多的证据表明，睡眠相关因素对此有贡献，但用于评估这种贡献的方法存在很大的不一致性，特别是在控制昼夜节律相位位置方面。在 9 名年轻成年参与者的 14 小时延长清醒期中，每隔一小时评估一次姿势控制。使用 3 分钟的睁眼和闭眼时间评估了中侧和前后摆动、压力中心（CoP）轨迹长度、面积和速度的力板参数。同时在恒常程序条件下评估了一项标准的精神运动警觉性测量。在控制个体昼夜节律相位位置的差异后，发现延长清醒期对前后摆动和精神运动警觉性有显著影响。这些数据表明，延长清醒期可能会增加跌倒或姿势控制受损的其他后果的风险。
