血管紧张素转换酶抑制剂与阿尔茨海默病患者的认知和功能衰退：一项观察性研究
Angiotensin converting enzyme inhibitors and cognitive and functional decline in patients with Alzheimer's disease: an observational study.
作者信息
Hajjar Ihab M, Keown Michelle, Lewis Paige, Almor Amit
机构信息
Institute for Aging Research/Hebrew SeniorLife, Harvard Medical School, and the Beth Israel Deconess Medical Center, Boston, Massachusetts 02131, USA.
出版信息
Am J Alzheimers Dis Other Demen. 2008 Feb-Mar;23(1):77-83. doi: 10.1177/1533317507309803.
Abstract
We previously reported that angiotensin converting enzyme inhibitors (ACEIs) decrease the rate of cognitive decline in elderly patients with hypertension, but their impact on patients with Alzheimer's disease (AD) is not known. A total of 62 elderly patients with AD were enrolled, and 52 completed the study for 6 months. Mini-Mental Status Examination (MMSE), Clock Draw Test (CDT), working memory (Digit Ordering), Instrumental Activities of Daily Living (IADL) scale, and the Screen for Caregiver Burden (SCB) were collected at baseline, 3 months, and 6 months. AD patients receiving ACEI (N = 15) demonstrated a slower rate of decline in digit forward (P = .003) and IADL scale (P = .003) and an improved measure of caregiver burden (P = .04) but not MMSE (P =.15) or CDT (P =.9) compared with those not receiving ACEI after adjusting for other risk factors. This study suggests that use of ACEI in AD patients is associated with slower rate of AD progression. A randomized clinical trial is needed to confirm our finding.
摘要
我们之前报道过，血管紧张素转换酶抑制剂（ACEIs）可降低老年高血压患者的认知衰退率，但其对阿尔茨海默病（AD）患者的影响尚不清楚。总共招募了62名老年AD患者，其中52名完成了为期6个月的研究。在基线、3个月和6个月时收集简易精神状态检查表（MMSE）、画钟试验（CDT）、工作记忆（数字排序）、日常生活活动能力量表（IADL）以及照顾者负担筛查量表（SCB）。在调整其他风险因素后，与未接受ACEI的AD患者相比，接受ACEI的AD患者（N = 15）在顺背数字广度（P = .003）和IADL量表方面（P = .003）衰退速度较慢，照顾者负担指标有所改善（P = .04），但在MMSE（P =.15）或CDT（P =.9）方面无差异。本研究表明，AD患者使用ACEI与AD进展速度较慢有关。需要进行一项随机临床试验来证实我们的发现。
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