Bâ Maryse Badan, Zanello Adriano, Varnier Marion, Koellner Vanessa, Merlo Marco C G
Division of Adult Psychiatry, Department of Psychiatry, Early Psychosis Program (JADE), University Hospitals of Geneva, Geneva, Switzerland.
J Nerv Ment Dis. 2008 Feb;196(2):153-6. doi: 10.1097/NMD.0b013e318162aa08.
In schizophrenic disorders, impairments in social functioning, neurocognition, and theory of mind (ToM) are frequently reported but little is known about the relationships between them. The aim of this study is twofold: (a) to compare neurocognition, social-functioning, and ToM in patients and controls and (b) to investigate whether impairments in these domains are related to psychiatric symptoms. Participants were 16 outpatients with schizophrenic disorders (DSM-IV), and 16 healthy controls. We administered neuropsychological tests, ToM, social functioning, and psychopathology measures. Patients and controls differed on most neurocognitive variables (memory, attention, executive functions). We also found significant differences in 1 ToM factor and 2 social measures. The latter were the only 2 related to manic-hostility and negative symptoms subscores of Brief Psychiatric Rating Scale. Our findings suggest that there is no direct relation between neurocognitive impairments and social dysfunctions.
在精神分裂症谱系障碍中，社会功能、神经认知和心理理论（ToM）方面的损害经常被报道，但它们之间的关系却鲜为人知。本研究的目的有两个：（a）比较患者和对照组在神经认知、社会功能和心理理论方面的差异；（b）研究这些领域的损害是否与精神症状有关。参与者包括16名精神分裂症谱系障碍（DSM-IV）门诊患者和16名健康对照者。我们进行了神经心理学测试、心理理论测试、社会功能测试和精神病理学测量。患者和对照组在大多数神经认知变量（记忆、注意力、执行功能）上存在差异。我们还发现心理理论的1个因子和2项社会测量指标存在显著差异。后者是仅有的与简明精神病评定量表的躁狂-敌意和阴性症状子量表相关的2项指标。我们的研究结果表明，神经认知损害与社会功能障碍之间没有直接关系。
