镰刀菌属产生的硫酸玉米赤霉烯酮的分离与鉴定
Isolation and characterization of zearalenone sulfate produced by Fusarium spp.
作者信息
Plasencia J, Mirocha C J
机构信息
Department of Plant Pathology, University of Minnesota, St. Paul 55108.
出版信息
Appl Environ Microbiol. 1991 Jan;57(1):146-50. doi: 10.1128/aem.57.1.146-150.1991.
Abstract
A water-soluble compound related to zearalenone was isolated from a culture of Fusarium graminearum 30 grown in rice. The structure of the novel metabolite was determined to be zearalenone-4-sulfate on the basis of fast-atom-bombardment mass spectrometry, proton nuclear magnetic resonance, UV spectroscopy, and by chemical and enzymatic reactions. Strains representing Fusarium equiseti, Fusarium sambucinum, and Fusarium roseum produced the sulfate conjugate as well. In the rat uterus enlargement bioassay, the metabolite or its hydrolysis product was found to retain the estrogenic activity characteristic of zearalenone. Natural occurrence of this novel metabolite might be significant because analytical methods devised for zearalenone in grain cannot detect the conjugate but the conjugate retains the biological properties of the mycotoxin when ingested by animals.
摘要
从在大米中培养的禾谷镰刀菌30中分离出一种与玉米赤霉烯酮有关的水溶性化合物。基于快原子轰击质谱、质子核磁共振、紫外光谱以及化学和酶促反应，确定该新型代谢产物的结构为玉米赤霉烯酮-4-硫酸盐。代表木贼镰刀菌、接骨木镰刀菌和粉红镰刀菌的菌株也产生硫酸盐共轭物。在大鼠子宫增大生物测定中，发现该代谢产物或其水解产物保留了玉米赤霉烯酮的雌激素活性特征。这种新型代谢产物的天然存在可能具有重要意义，因为针对谷物中玉米赤霉烯酮设计的分析方法无法检测到共轭物，但该共轭物在被动物摄入时保留了霉菌毒素的生物学特性。
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