Francis J, Snee M
Medical Research Council Environmental Epidemiology Unit (University of Southampton), Southampton General Hospital.
Clin Radiol. 1991 May;43(5):343-6. doi: 10.1016/s0009-9260(05)80545-8.
A case control study of 67 infants with trisomy and 67 apparently normal controls matched to each case for sex, date of birth and age of mother at birth has been carried out. Cases were compared with controls for exposure of their mothers to medical radiography prior to conception as recorded in medical records. The total number and type of radiographs were similar in both groups. The relative risk of trisomy for a radiographic examination, involving direct irradiation of the ovaries, prior to conception was 0.8 (95% confidence interval 0.34-1.83). The estimated mean nominal ovarian doses for case and control mothers were 2.19 and 2.41 mGy respectively. Therefore this study does not show an increased risk of giving birth to a child with trisomy for mothers whose ovaries have been exposed to medical radiation. However, because of the small numbers of cases studied and the limited data available a risk cannot be excluded. It is unlikely that a radiograph involving direct exposure of the maternal gonads could increase the risk of a subsequent pregnancy affected by trisomy by more than two.
开展了一项病例对照研究，研究对象为67例三体综合征婴儿以及67例明显正常的对照婴儿，对照婴儿在性别、出生日期和母亲分娩时年龄方面与各病例相匹配。根据病历记录，比较病例组和对照组的母亲在受孕前接受医学放射检查的情况。两组的X光片总数和类型相似。受孕前涉及卵巢直接照射的放射检查导致三体综合征的相对风险为0.8（95%置信区间0.34 - 1.83）。病例组和对照组母亲的估计平均标称卵巢剂量分别为2.19和2.41毫戈瑞。因此，本研究未显示卵巢接受过医学辐射的母亲生育三体综合征患儿的风险增加。然而，由于研究的病例数量较少且可用数据有限，不能排除风险。涉及母体性腺直接照射的X光片使后续妊娠受三体综合征影响的风险增加超过两倍的可能性不大。
