Parsons J Kellogg, Newman Vicky, Mohler James L, Pierce John P, Paskett Electra, Marshall James
Moores Cancer Center, University of California-San Diego, La Jolla, California, USA.
Urology. 2008 Sep;72(3):633-7. doi: 10.1016/j.urology.2007.11.050. Epub 2008 Feb 15.
To evaluate the feasibility of implementing a diet-based intervention in men with prostate cancer.
Seventy-four men aged 50 to 80 years with biopsy-proven adenocarcinoma of the prostate were randomized to receive either telephone-based dietary counseling or standardized, written nutritional information. Telephone dietary counseling targets included increased intakes of vegetables (particularly cruciferous vegetables and tomato products), whole grains, and beans/legumes. Dietary intakes and plasma carotenoid levels were assessed at baseline and at 6 months' follow-up.
In the intervention arm, mean daily intakes of total vegetables, crucifers, tomato products, and beans/legumes increased by 76%, 143%, 292%, and 95%, respectively, whereas fat intake decreased by 12% (P = 0.02). In the control arm, there were no significant changes in mean intakes of total vegetables, tomato products, crucifers, beans/legumes, or fat. Similarly, in the intervention arm, mean plasma levels of alpha-carotene, beta-carotene, lutein, lycopene, and total carotenoids increased by 33%, 36%, 19%, 30%, and 26%, respectively (P <0.05). In the control arm, there were no significant changes in plasma levels of alpha- or beta-carotene, lutein, lycopene, or total carotenoids.
Telephone-based dietary counseling increases vegetable intake, decreases fat intake, and significantly increases plasma levels of potentially anticarcinogenic carotenoids in men with prostate cancer. These data support the feasibility of implementing clinical trials of dietary intervention in men with prostate cancer.
评估对前列腺癌男性实施基于饮食的干预措施的可行性。
74名年龄在50至80岁之间、经活检证实为前列腺腺癌的男性被随机分为两组，分别接受电话饮食咨询或标准化的书面营养信息。电话饮食咨询的目标包括增加蔬菜（特别是十字花科蔬菜和番茄制品）、全谷物和豆类的摄入量。在基线和随访6个月时评估饮食摄入量和血浆类胡萝卜素水平。
在干预组中，蔬菜、十字花科蔬菜、番茄制品和豆类的平均每日摄入量分别增加了76%、143%、292%和95%，而脂肪摄入量减少了12%（P = 0.02）。在对照组中，蔬菜、番茄制品、十字花科蔬菜、豆类或脂肪的平均摄入量没有显著变化。同样，在干预组中，α-胡萝卜素、β-胡萝卜素、叶黄素、番茄红素和总类胡萝卜素的平均血浆水平分别增加了33%、36%、19%、30%和26%（P <0.05）。在对照组中，α-或β-胡萝卜素、叶黄素、番茄红素或总类胡萝卜素的血浆水平没有显著变化。
电话饮食咨询可增加前列腺癌男性的蔬菜摄入量，减少脂肪摄入量，并显著提高潜在抗癌类胡萝卜素的血浆水平。这些数据支持对前列腺癌男性实施饮食干预临床试验的可行性。
