Sniadack Mercedes M, Neff Linda J, Swerdlow David L, Schieber Richard A, McCauley Mary M, Mootrey Gina T
National Immunization Program, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Clin Infect Dis. 2008 Mar 15;46 Suppl 3:S251-7. doi: 10.1086/524741.
Limited information exists regarding intermediate or long-term consequences of cardiac adverse events (CAEs) after smallpox vaccination. We conducted follow up at 5-12 months after vaccination of 203 US civilian vaccinees who reported a possible CAE. Among 31 of the 33 with confirmed CAEs, at least 1 health-related quality-of-life change persisted for approximately 48%; approximately 87% missed work (average, 11.5 days). Among 168 of the 170 case patients with other reported cardiovascular conditions, at least 1 health-related quality-of-life change persisted for approximately 40%; almost 49% missed work (average, 10.2 days). Almost all vaccinees with possible CAEs were working the same number of hours at follow-up compared with before vaccination. Although intermediate-term consequences among possible postvaccination CAEs were not considered serious, lost days of work and a decline in health-related quality of life at the time of follow-up were common, resulting in personal economic and quality-of-life burden.
关于天花疫苗接种后心脏不良事件（CAEs）的中期或长期后果，现有信息有限。我们对203名报告可能出现CAE的美国平民疫苗接种者在接种后5至12个月进行了随访。在33例确诊CAEs的患者中，有31例至少有1项与健康相关的生活质量变化持续存在，约占48%；约87%的患者误工（平均11.5天）。在170例报告有其他心血管疾病的病例患者中，有168例至少有1项与健康相关的生活质量变化持续存在，约占40%；近49%的患者误工（平均10.2天）。几乎所有可能出现CAEs的疫苗接种者在随访时的工作时长与接种前相同。虽然接种疫苗后可能出现的CAEs的中期后果不被认为严重，但随访时误工天数和与健康相关的生活质量下降很常见，导致个人经济和生活质量负担。
