Villegas Raquel, Shu Xiao Ou, Gao Yu-Tang, Yang Gong, Elasy Tom, Li Honglan, Zheng Wei
Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Nashville, TN 37203-1738, USA.
J Nutr. 2008 Mar;138(3):574-80. doi: 10.1093/jn/138.3.574.
We examined associations between fruit and vegetable intake and the incidence of type 2 diabetes (T2D) in a population-based prospective study of 64,191 women with no history of T2D or other chronic diseases at study recruitment and with valid dietary information. Dietary intake was assessed by in-person interviews using a validated FFQ. During 297,755 person-years of follow-up, 1608 new cases of T2D were documented. We used a Cox regression model to evaluate the association of fruit and vegetable intake (g/d) with the risk of T2D. Quintiles of vegetable intake and T2D were inversely associated. The relative risk for T2D for the upper quintile relative to the lower quintile of vegetable intake was 0.72 (95%CI: 0.61-0.85; P < 0.01) in multivariate analysis. Individual vegetable groups were all inversely and significantly associated with the risk of T2D. Fruit intake was not associated with the incidence of diabetes in this population. Our data suggest that vegetable consumption may protect against the development of T2D.
在一项基于人群的前瞻性研究中,我们调查了64191名在研究招募时无2型糖尿病(T2D)或其他慢性病病史且有有效饮食信息的女性中,水果和蔬菜摄入量与2型糖尿病发病率之间的关联。通过使用经过验证的食物频率问卷(FFQ)进行面对面访谈来评估饮食摄入量。在297755人年的随访期间,记录了1608例新的T2D病例。我们使用Cox回归模型来评估水果和蔬菜摄入量(克/天)与T2D风险之间的关联。蔬菜摄入量的五分位数与T2D呈负相关。在多变量分析中,蔬菜摄入量最高五分位数相对于最低五分位数的T2D相对风险为0.72(95%置信区间:0.61 - 0.85;P < 0.01)。各个蔬菜组均与T2D风险呈负相关且具有显著性。在该人群中,水果摄入量与糖尿病发病率无关。我们的数据表明,食用蔬菜可能预防T2D的发生。