Division of Neonatology, Perrino Hospital, 72100 Brindisi, Italy.
PPAR Res. 2008;2008:359267. doi: 10.1155/2008/359267.
There is growing evidence that male as well as female reproductive function has been declining in human and wildlife populations over the last 40 years. Several factors such as lifestyle or environmental xenobiotics other than genetic factors may play a role in determining adverse effects on reproductive health. Among the environmental xenobiotics phthalates, a family of man-made pollutants are suspected to interfere with the function of the endocrine system and therefore to be endocrine disruptors. The definition of endocrine disruption is today extended to broader endocrine regulations, and includes activation of metabolic sensors, such as the peroxisome proliferator-activated receptors (PPARs). Toxicological studies have shown that phthalates can activate a subset of PPARs. Here, we analyze the epidemiological and experimental evidence linking phthalate exposure to both PPAR activation and adverse effects on male and female reproductive health.
越来越多的证据表明，在过去的 40 年中，男性和女性的生殖功能都在下降，无论是在人类还是野生动物种群中。除了遗传因素外，生活方式或环境污染物等多种因素可能在决定生殖健康的不良影响方面发挥作用。在环境污染物邻苯二甲酸酯中，这是一类人造污染物，被怀疑会干扰内分泌系统的功能，因此是内分泌干扰物。内分泌干扰物的定义如今已扩展到更广泛的内分泌调节，包括代谢传感器的激活，如过氧化物酶体增殖物激活受体 (PPAR)。毒理学研究表明，邻苯二甲酸酯可以激活一组特定的 PPAR。在这里，我们分析了将邻苯二甲酸酯暴露与 PPAR 激活以及对男性和女性生殖健康的不良影响联系起来的流行病学和实验证据。
