Nam Do Jin, Kim Yeji, Yang Eun Hye, Lee Hyo Choon, Ryoo Jae-Hong
Department of Occupational & Environmental Medicine, Kyung Hee University Hospital, Seoul, Korea.
Department of Occupational & Environmental Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
Ann Occup Environ Med. 2020 Sep 18;32:e34. doi: 10.35371/aoem.2020.32.e34. eCollection 2020.
We aimed to determine relationship diabetes according to urinary phthalate metabolites using adult data from Korean National Environmental Health Survey cycle 3 (2015-2017).
This study was conducted on 3,781 adults aged 19 years and older (1,648 men and 2,133 women) based on KoNEHS cycle 3. Participants' data were analyzed by gender; Relationship between phthalate metabolites in the urine and diabetes was analyzed by dividing the sociodemographic variables, health behavior-related variables, and urinary phthalate metabolite concentrations into quartiles. To determine the relationship between urinary phthalate metabolites and the prevalence of diabetes, the odds ratio (OR) was calculated using logistic regression analysis.
Based on the 1st quartile of each metabolite, the ORs for di-2-ethylhexyl phthalate (DEHP) (4th quartile), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) (2nd quartile, 3rd quartile and 4th quartile), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) (4th quartile), mono-(2-ethyl-5-carboxypentyl) phthalate (MECCP) (4th quartile), mono-n-butyl phthalate (MnBP) (3rd quartile and 4th quartile), mono-benzyl phthalate (MBzP) (2nd quartile) and 4th quartile), and mono (3-carboxypropyl) phthalate (MCPP) (3rd quartile and 4th quartile) were significantly higher after the adjustment in men. The ORs for DEHP (2nd quartile, 3rd quartile and 4th quartile), MEHHP (2nd quartile, 3rd quartile and 4th quartile), MEOHP (4th quartile), MECCP (4th quartile), MBzP (4th quartile), and MCPP (4th quartile) were significantly higher after the adjustment in women.
This study investigated relationship between urinary phthalate metabolites and diabetes. The higher urinary phthalate metabolites, the higher the prevalence of diabetes. Further regulation of phthalate may be needed, and further studies are warranted to confirm the association between phthalate concentration and other chronic diseases (such as hypertension, hyperlipidemia, and cardiovascular disease).
我们旨在利用韩国国家环境健康调查第3轮（2015 - 2017年）的成人数据，确定尿中邻苯二甲酸酯代谢物与糖尿病之间的关系。
本研究基于韩国国家环境健康调查第3轮，对3781名19岁及以上的成年人（1648名男性和2133名女性）进行。参与者的数据按性别进行分析；通过将社会人口统计学变量、健康行为相关变量和尿中邻苯二甲酸酯代谢物浓度分为四分位数，分析尿中邻苯二甲酸酯代谢物与糖尿病之间的关系。为了确定尿中邻苯二甲酸酯代谢物与糖尿病患病率之间的关系，使用逻辑回归分析计算优势比（OR）。
基于每种代谢物的第一四分位数，在男性中，邻苯二甲酸二（2 - 乙基己基）酯（DEHP）（第四四分位数）、单（2 - 乙基 - 5 - 羟基己基）邻苯二甲酸酯（MEHHP）（第二四分位数、第三四分位数和第四四分位数）、单（2 - 乙基 - 5 - 氧代己基）邻苯二甲酸酯（MEOHP）（第四四分位数）、单（2 - 乙基 - 5 - 羧基戊基）邻苯二甲酸酯（MECCP）（第四四分位数）、邻苯二甲酸单正丁酯（MnBP）（第三四分位数和第四四分位数）、邻苯二甲酸单苄酯（MBzP）（第二四分位数和第四四分位数）以及邻苯二甲酸单（3 - 羧基丙基）酯（MCPP）（第三四分位数和第四四分位数）在调整后显著更高。在女性中，DEHP（第二四分位数、第三四分位数和第四四分位数）、MEHHP（第二四分位数、第三四分位数和第四四分位数）、MEOHP（第四四分位数）、MECCP（第四四分位数）、MBzP（第四四分位数）和MCPP（第四四分位数）在调整后的OR值显著更高。
本研究调查了尿中邻苯二甲酸酯代谢物与糖尿病之间的关系。尿中邻苯二甲酸酯代谢物水平越高，糖尿病患病率越高。可能需要进一步规范邻苯二甲酸酯的使用，并且有必要进行进一步研究以证实邻苯二甲酸酯浓度与其他慢性病（如高血压、高脂血症和心血管疾病）之间的关联。
