肝素的固定化：方法与应用
Immobilization of heparin: approaches and applications.
作者信息
Murugesan Saravanababu, Xie Jin, Linhardt Robert J
机构信息
Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
出版信息
Curr Top Med Chem. 2008;8(2):80-100. doi: 10.2174/156802608783378891.
Abstract
Heparin, an anticoagulant, has been used in many forms to treat various diseases. These forms include soluble heparin and heparin immobilized to supporting matrices by physical adsorption, by covalent chemical methods and by photochemical attachment. These immobilization methods often require the use of spacers or linkers. This review examines and compares various techniques that have been used for the immobilization of heparin as well as applications of these immobilized heparins. In the applications reviewed, immobilized heparin is compared with soluble heparin for efficient and versatile use in each of the various applications.
摘要
肝素作为一种抗凝剂，已被用于多种形式来治疗各种疾病。这些形式包括可溶性肝素以及通过物理吸附、共价化学方法和光化学附着固定在支撑基质上的肝素。这些固定方法通常需要使用间隔物或连接体。本综述研究并比较了用于固定肝素的各种技术以及这些固定化肝素的应用。在所综述的应用中，将固定化肝素与可溶性肝素进行比较，以考察其在各种应用中的高效性和通用性。
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