肝素的固定化：方法与应用
Immobilization of heparin: approaches and applications.
作者信息
Murugesan Saravanababu, Xie Jin, Linhardt Robert J
机构信息
Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
出版信息
Curr Top Med Chem. 2008;8(2):80-100. doi: 10.2174/156802608783378891.
Abstract
Heparin, an anticoagulant, has been used in many forms to treat various diseases. These forms include soluble heparin and heparin immobilized to supporting matrices by physical adsorption, by covalent chemical methods and by photochemical attachment. These immobilization methods often require the use of spacers or linkers. This review examines and compares various techniques that have been used for the immobilization of heparin as well as applications of these immobilized heparins. In the applications reviewed, immobilized heparin is compared with soluble heparin for efficient and versatile use in each of the various applications.
摘要
肝素作为一种抗凝剂，已被用于多种形式来治疗各种疾病。这些形式包括可溶性肝素以及通过物理吸附、共价化学方法和光化学附着固定在支撑基质上的肝素。这些固定方法通常需要使用间隔物或连接体。本综述研究并比较了用于固定肝素的各种技术以及这些固定化肝素的应用。在所综述的应用中，将固定化肝素与可溶性肝素进行比较，以考察其在各种应用中的高效性和通用性。
相似文献
1
Immobilization of heparin: approaches and applications.
Curr Top Med Chem. 2008;8(2):80-100. doi: 10.2174/156802608783378891.
2
Modified heparin inhibits P-selectin-mediated cell adhesion of human colon carcinoma cells to immobilized platelets under dynamic flow conditions.
J Biol Chem. 2004 Jul 9;279(28):29202-10. doi: 10.1074/jbc.M312951200. Epub 2004 May 7.
3
Synthesis and evaluation of heparin immobilized "side-on" to polystyrene microspheres coated with end-group activated polyethylene oxide.
Int J Biol Macromol. 2010 Aug 1;47(2):98-103. doi: 10.1016/j.ijbiomac.2010.05.015. Epub 2010 May 26.
4
New methods for surface modification and covalent attachment of heparin.
Med Device Technol. 1998 Jan-Feb;9(1):24-7.
5
Physicochemical and blood compatibility characterization of polypyrrole surface functionalized with heparin.
Biotechnol Bioeng. 2003 Nov 5;84(3):305-13. doi: 10.1002/bit.10757.
6
Synthesis and anticoagulant activity of heparin immobilized "end-on" to polystyrene microspheres coated with end-group activated polyethylene oxide.
J Biomed Mater Res B Appl Biomater. 2010 Jul;94(1):187-95. doi: 10.1002/jbm.b.31640.
7
[Review of heparin immobilization technique].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2007 Apr;24(2):466-9.
8
Biological properties of synthetic glycoconjugate mimics of heparin comprising different molecular spacers.
Bioorg Med Chem Lett. 1998 Aug 18;8(16):2081-6. doi: 10.1016/s0960-894x(98)00382-5.
9
Heparin surface immobilization through hydrophilic spacers: thrombin and antithrombin III binding kinetics.
J Biomater Sci Polym Ed. 1994;6(1):1-13. doi: 10.1163/156856295x00715.
10
Surface Modification of Reduced Graphene Oxide Beads: Integrating Efficient Endotoxin Adsorption and Improved Blood Compatibility.
ACS Appl Bio Mater. 2021 Jun 21;4(6):4896-4906. doi: 10.1021/acsabm.0c01666. Epub 2021 May 7.
引用本文的文献
1
Ex vivo evaluation of blood coagulation on endothelial glycocalyx-inspired surfaces using thromboelastography.
In Vitro Model. 2021 Oct 29;1(1):59-71. doi: 10.1007/s44164-021-00001-w. eCollection 2022 Feb.
2
Synthesis and Optimization of Collagen-targeting Peptide-Glycosaminoglycans for Inhibition of Platelets Following Endothelial Injury.
Proteoglycan Res. 2023 Apr 1;1(2). doi: 10.1002/pgr2.3. Epub 2023 Jun 1.
3
Exploring single-molecule interactions: heparin and FGF-1 proteins through solid-state nanopores.
Nanoscale. 2024 May 2;16(17):8352-8360. doi: 10.1039/d4nr00274a.
4
Unravelling Surface Modification Strategies for Preventing Medical Device-Induced Thrombosis.
Adv Healthc Mater. 2024 Jan;13(1):e2301039. doi: 10.1002/adhm.202301039. Epub 2023 Oct 5.
5
Challenge of material haemocompatibility for microfluidic blood-contacting applications.
Front Bioeng Biotechnol. 2023 Aug 17;11:1249753. doi: 10.3389/fbioe.2023.1249753. eCollection 2023.
6
Grafting Strategies of Oxidation-Prone Coiled-Coil Peptides for Protein Capture in Bioassays: Impact of Orientation and the Oxidation State.
ACS Omega. 2023 Jul 28;8(31):28301-28313. doi: 10.1021/acsomega.3c02172. eCollection 2023 Aug 8.
7
Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates.
Nat Commun. 2023 Jul 4;14(1):3939. doi: 10.1038/s41467-023-39314-7.
8
Strategies for surface coatings of implantable cardiac medical devices.
Front Bioeng Biotechnol. 2023 May 9;11:1173260. doi: 10.3389/fbioe.2023.1173260. eCollection 2023.
9
Xanthan-Based Materials as a Platform for Heparin Delivery.
Molecules. 2023 Mar 18;28(6):2757. doi: 10.3390/molecules28062757.
10
How COVID-19 and other pathological conditions and medical treatments activate our intravascular innate immune system.
Front Immunol. 2023 Feb 3;13:1030627. doi: 10.3389/fimmu.2022.1030627. eCollection 2022.
本文引用的文献
1
Ionic liquid-derived blood-compatible composite membranes for kidney dialysis.
J Biomed Mater Res B Appl Biomater. 2006 Nov;79(2):298-304. doi: 10.1002/jbm.b.30542.
2
Blood compatible carbon nanotubes--nano-based neoproteoglycans.
Langmuir. 2006 Apr 11;22(8):3461-3. doi: 10.1021/la0534468.
3
Preparation of biopolymer fibers by electrospinning from room temperature ionic liquids.
Biomacromolecules. 2006 Feb;7(2):415-8. doi: 10.1021/bm050837s.
4
Designing materials for biology and medicine.
Nature. 2004 Apr 1;428(6982):487-92. doi: 10.1038/nature02388.
5
Hemocompatibility of polyacrylonitrile dialysis membrane immobilized with chitosan and heparin conjugate.
Biomaterials. 2004 May;25(10):1947-57. doi: 10.1016/j.biomaterials.2003.08.027.
6
Covalent immobilization of chitosan and heparin on PLGA surface.
Int J Biol Macromol. 2003 Nov;33(1-3):95-100. doi: 10.1016/s0141-8130(03)00072-2.
7
Physicochemical and blood compatibility characterization of polypyrrole surface functionalized with heparin.
Biotechnol Bioeng. 2003 Nov 5;84(3):305-13. doi: 10.1002/bit.10757.
8
2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity.
J Med Chem. 2003 Jun 19;46(13):2551-64. doi: 10.1021/jm030176m.
9
Further evidence that periodate cleavage of heparin occurs primarily through the antithrombin binding site.
Carbohydr Res. 2002 Nov 19;337(21-23):2239-43. doi: 10.1016/s0008-6215(02)00229-x.
10
Covalent immobilization of chitosan/heparin complex with a photosensitive hetero-bifunctional crosslinking reagent on PLA surface.
Biomaterials. 2002 Dec;23(23):4657-65. doi: 10.1016/s0142-9612(02)00215-6.
Zotero 插件