Wang Xiao-Ping, Liu Jian-Min, Zhao Yong-Bo
Department of Neurology, Shanghai first People's Hospital, Shanghai Jiao-Tong University, Shanghai, PR China.
Med Hypotheses. 2008;71(1):14-21. doi: 10.1016/j.mehy.2007.12.015. Epub 2008 Mar 4.
Migraine is a periodic disorder with a worldwide prevalence of 5-19%. This study raises the hypothesis of a sex-influenced genetic model of migraine transmission. That migraine may be sex-influenced (autosomal dominant in females and autosomal recessive in males) is supported by such evidences as: (1) familial hemiplegic migraine, subtype from migraine with aura, being dominantly assigned to autosomal chromosome 19p, 1q, and 2q; (2) a male to female prevalence of 1:2-4; (3) primarily young age of onset; (4) provocation by pharmaceutical contraception; (5) induction by menstruation; (6) self-limitation after menopause; and (7) only female migraineurs in some migraine families. Female sex hormone in the migraineur may be the key factor, comparable to the male sex hormone: androgen, in the genetic baldness. Migraine appears caused by a multi-factor inheritance with higher rates among females than males, and influenced by environmental and cultural factors.
偏头痛是一种周期性疾病，全球患病率为5%-19%。本研究提出了偏头痛遗传传播的性别影响模型假说。偏头痛可能受性别影响（女性为常染色体显性遗传，男性为常染色体隐性遗传），以下证据支持该观点：（1）家族性偏瘫性偏头痛，偏头痛伴先兆的一种亚型，主要定位于常染色体19p、1q和2q；（2）男女患病率为1:2-4；（3）发病年龄主要在年轻时；（4）药物避孕可诱发；（5）月经可诱发；（6）绝经后自行缓解；（7）某些偏头痛家族中只有女性偏头痛患者。偏头痛患者体内的女性性激素可能是关键因素，这与男性性激素——雄激素在遗传性秃发中的作用类似。偏头痛似乎是由多因素遗传导致的，女性患病率高于男性，且受环境和文化因素影响。
