Pollard M, Luckert P H, Sporn M B
Lobund Laboratory, University of Notre Dame, Indiana 46556.
Cancer Res. 1991 Jul 1;51(13):3610-1.
We report for the first time that a synthetic retinoid, N-(4-hydroxyphenyl)retinamide, can prevent the development of both primary and metastatic tumors in an animal model of metastasizing primary prostate cancer. Prostatic adenocarcinomas were induced in high incidence in Lobund-Wistar rats by initiation with methylnitrosourea i.v. and promotion with testosterone. Feeding of N-(4-hydroxyphenyl)retinamide to these rats during the latency period markedly diminished the final incidence of both primary and metastatic prostate carcinomas.
我们首次报告，一种合成类视黄醇N-(4-羟基苯基)视黄酰胺，在转移性原发性前列腺癌动物模型中可预防原发性和转移性肿瘤的发生。通过静脉注射甲基亚硝基脲启动并使用睾酮促进，在Lobund-Wistar大鼠中高发病率诱导前列腺腺癌。在潜伏期向这些大鼠喂食N-(4-羟基苯基)视黄酰胺，显著降低了原发性和转移性前列腺癌的最终发病率。
