Yavas Guliz Fatma, Ozturk Faruk, Kusbeci Tuncay, Ermis Sitki Samet, Yilmazer Mehmet, Cevrioglu Serhan, Aktepe Fatma, Kose Songul
School of Medicine, Department of Ophthalmology, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Curr Eye Res. 2008 Feb;33(2):133-8. doi: 10.1080/02713680701858410.
Polycystic ovary syndrome (PCOS) is an endocrinopathy characterized by chronic anovulation and hyperandrogenism where hyperinsulinemia can be seen. Hormonal changes can affect meibomian gland function. In this study, we evaluated tear function in PCOS.
Twenty-seven women having PCOS and 22 normal individuals aged between 18-42 years were enrolled in the study. Patients were asked about dry eye symptoms. Schirmer test, tear film breakup time, and rose Bengal staining were performed. Conjunctival brush cytology specimens were obtained and goblet cell count was done.
Dry eye symptoms were more frequent in subjects with PCOS (p=0.025). Mean breakup time was shorter in women with PCOS (p=0.034). Schirmer test results, rose Bengal staining scores, and goblet cell count were not different between groups (p=0.48, p=0.18, p=0.82, respectively).
Meibomian gland function and tear film lipid layer can be affected in cases with PCOS.
多囊卵巢综合征（PCOS）是一种以内分泌紊乱为特征的疾病，表现为慢性无排卵和高雄激素血症，常伴有高胰岛素血症。激素变化会影响睑板腺功能。在本研究中，我们评估了PCOS患者的泪液功能。
本研究纳入了27名年龄在18 - 42岁之间的PCOS女性患者和22名正常个体。询问患者干眼症状。进行了泪液分泌试验、泪膜破裂时间和孟加拉玫瑰红染色检查。获取结膜刷片细胞学标本并进行杯状细胞计数。
PCOS患者干眼症状更为常见（p = 0.025）。PCOS女性的平均泪膜破裂时间较短（p = 0.034）。两组之间泪液分泌试验结果、孟加拉玫瑰红染色评分和杯状细胞计数无差异（分别为p = 0.48、p = 0.18、p = 0.82）。
PCOS患者的睑板腺功能和泪膜脂质层可能受到影响。
