Christopoulou Clio, Graikou Konstantia, Chinou Ioanna
Division of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens GR-15771.
Chem Biodivers. 2008 Feb;5(2):318-23. doi: 10.1002/cbdv.200890029.
The first phytochemical investigation of Scabiosa hymettia led to the isolation and characterization of nine known compounds, 2-10, and of the new kaempferol derivative 1. In total, two flavonoids, three coumarins, three iridoids, and two phenolic constituents were obtained. The chemosystematic value of these compounds, as well as the metabolic relationship between swertiamarin (6) and the other isolated coumarins, are discussed. Both the extracts as well as all isolated constituents of S. hymettia were evaluated for their antimicrobial activities against six Gram-positive or Gram-negative bacteria, and against three human pathogenic fungi. The new compound 1 was found to exhibit the highest activity against all organisms tested.
对 Hymettia 山萝卜的首次植物化学研究导致分离并鉴定出九种已知化合物（2 - 10）以及新的山柰酚衍生物 1。总共获得了两种黄酮类化合物、三种香豆素、三种环烯醚萜和两种酚类成分。讨论了这些化合物的化学分类学价值，以及獐牙菜苦苷（6）与其他分离出的香豆素之间的代谢关系。对 Hymettia 山萝卜的提取物以及所有分离出的成分针对六种革兰氏阳性或革兰氏阴性细菌和三种人类致病真菌的抗菌活性进行了评估。发现新化合物 1 对所有测试的生物体表现出最高活性。
