谷精草中的抗菌酚类成分。

Antibacterial phenolic components from Eriocaulon buergerianum.

作者信息

Fang Jing-Jing, Ye Guan, Chen Wen-Liang, Zhao Wei-Min

机构信息

Central Research Institute of Shanghai Pharmaceutical Group, Shanghai 201203, China.

出版信息

Phytochemistry. 2008 Mar;69(5):1279-86. doi: 10.1016/j.phytochem.2007.11.014. Epub 2008 Jan 11.

DOI:10.1016/j.phytochem.2007.11.014

PMID:18191163

Abstract

Five phenolic components, 1,3,6-trihydroxy-2,5,7-trimethoxyxanthone (1), 7,3'-dihydroxy-5,4',5'-trimethoxyisoflavone (2), toralactone-9-O-beta-D-glucopyranoside (3), patuletin-3-O-[2-O-E-feruloyl-beta-d-glucopyranosyl-(1-->6)-beta-d-glucopyranoside] (4), patuletin-3-O-[beta-d-glucopyranosyl-(1-->3)-2-O-E-caffeoyl-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside] (5), along with 19 known compounds were isolated from Eriocaulon buergerianum (Eriocaulaceae). Their structures were determined by spectroscopic and chemical methods. All 24 isolated compounds were tested against the pathogenic bacteria Staphylococcus aureus (ATCC 25923); as a result, 10 compounds were found to exhibit antibacterial activity with MICs ranging from 32 to 256 microg/ml.

摘要

从谷精草（谷精草科）中分离出了5种酚类成分，1,3,6 - 三羟基 - 2,5,7 - 三甲氧基呫吨酮（1）、7,3'-二羟基 - 5,4',5'-三甲氧基异黄酮（2）、托拉内酯 - 9 - O - β - D - 吡喃葡萄糖苷（3）、紫铆亭 - 3 - O - [2 - O - E - 阿魏酰基 - β - D - 吡喃葡萄糖基 - (1→6) - β - D - 吡喃葡萄糖苷]（4）、紫铆亭 - 3 - O - [β - D - 吡喃葡萄糖基 - (1→3) - 2 - O - E - 咖啡酰基 - β - D - 吡喃葡萄糖基 - (1→6) - β - D - 吡喃葡萄糖苷]（5），以及19种已知化合物。通过光谱和化学方法确定了它们的结构。对所有24种分离出的化合物针对病原菌金黄色葡萄球菌（ATCC 25923）进行了测试；结果发现，10种化合物表现出抗菌活性，其最低抑菌浓度范围为32至256微克/毫升。