Macchia Alejandro, Monte Simona, Pellegrini Fabio, Romero Marilena, Ferrante Daniel, Doval Hernán, D'Ettorre Antonio, Maggioni Aldo Pietro, Tognoni Gianni
Department of Clinical Pharmacology and Epidemiology, Santa Maria Imbaro, Chieti, Italy.
Eur J Clin Pharmacol. 2008 Jun;64(6):627-34. doi: 10.1007/s00228-008-0464-z.
Current strategies for avoiding atrial fibrillation (AF) are of limited value. We aim to assess the relationship between omega-3 fatty acids (n-3 PUFA) and AF occurrence in post-myocardial infarction (MI) patients.
A population study, linking hospital discharge records, prescription databases, and vital statistics, was conducted and included all consecutive patients with MI (ICD-9: 410) in six Italian local health authorities over a 3-year period. A propensity score (PS)-based, 5-to-1, greedy 1:1 matching algorithm was used to check consistency of results. Sensitivity analysis was performed to assess the robustness of findings.
N-3 PUFA reduced the relative risk of the hospitalization for AF [hazard ratio (HR) 0.19, 95% CI 0.07-0.51] and was associated with a further and complementary reduction in all-cause mortality (HR 0.15, 95% CI 0.05-0.46). PS-based matched analysis and sensitivity analysis confirmed the main results.
n-3 PUFA reduced both all-cause mortality and incidence of 1-year AF in patients hospitalized with MI.
目前用于预防心房颤动（AF）的策略价值有限。我们旨在评估ω-3脂肪酸（n-3多不饱和脂肪酸）与心肌梗死（MI）后患者发生AF之间的关系。
开展了一项基于人群的研究，该研究将医院出院记录、处方数据库和人口动态统计数据相联系，纳入了意大利六个地方卫生当局在3年期间内所有连续的MI患者（国际疾病分类第九版：410）。采用基于倾向评分（PS）的5比1贪婪1比1匹配算法来检验结果的一致性。进行敏感性分析以评估研究结果的稳健性。
n-3多不饱和脂肪酸降低了AF住院的相对风险[风险比（HR）0.19，95%置信区间0.07 - 0.51]，并与全因死亡率的进一步互补性降低相关（HR 0.15，95%置信区间0.05 - 0.46）。基于PS的匹配分析和敏感性分析证实了主要结果。
n-3多不饱和脂肪酸降低了MI住院患者的全因死亡率和1年AF发病率。
