Brandon Anna R, Trivedi Madhukar H, Hynan Linda S, Miltenberger Paula D, Labat Dana Broussard, Rifkin Jamie B, Stringer C Allen
University of Texas Southwestern Medical Center at Dallas, Dallas, Tex 75390-9066, USA.
J Clin Psychiatry. 2008 Apr;69(4):635-43. doi: 10.4088/jcp.v69n0417.
Little is known about depression during pregnancy in women with high maternal or fetal risk, as this population is often excluded from research samples. The aim of this study was to evaluate depressive symptoms and known risk factors for depression in a group of women hospitalized with severe obstetric risk.
In the antenatal unit, 129 inpatients completed the Edinburgh Postnatal Depression Scale (EPDS), the Dyadic Adjustment Scale (DAS), and the Maternal Antenatal Attachment Scale (MAAS) from October 2005 through December 2006. A subset of women were administered the Mood Disorders module of the Structured Clinical Interview for DSM-IV Axis I Disorders based on a score of > or = 11 on the EPDS. Obstetric complications were classified according to the Hobel Risk Assessment for Prematurity.
Fifty-seven of the 129 women (44.2%) scored 11 or greater on the EPDS, and at least 25/129 (19.4%) met the DSM-IV criteria for major depressive disorder. Mothers reporting high attachment to the fetus on the MAAS reported lower severity of depressive symptoms (rho = -0.33, p < .0001); those reporting interpersonal relationship dissatisfaction on the DAS endorsed higher depressive severity (rho = -0.21, p = .02). Severity of obstetric risk was unrelated to depression, but one complication, incompetent cervix, was positively associated with level of depressive symptomatology.
Findings indicate a higher prevalence rate of major depressive disorder in women with severe obstetric risk than that reported in low-risk pregnancy samples, suggesting the need for routine depression screening to identify those who need treatment. Fewer depressive symptoms were reported by mothers reporting strong maternal fetal attachment and greater relationship satisfaction.
对于具有高孕产妇或胎儿风险的女性在孕期的抑郁情况了解甚少,因为这一人群往往被排除在研究样本之外。本研究的目的是评估一组因严重产科风险而住院的女性的抑郁症状及已知的抑郁风险因素。
在产前病房,从2005年10月至2006年12月,129名住院患者完成了爱丁堡产后抑郁量表(EPDS)、二元调适量表(DAS)和孕产妇产前依恋量表(MAAS)。根据EPDS得分≥11分,对一部分女性进行了《精神疾病诊断与统计手册》第四版轴I障碍结构化临床访谈中的情绪障碍模块测试。产科并发症根据霍贝尔早产风险评估进行分类。
129名女性中有57名(44.2%)在EPDS上得分≥11分,且至少25/129名(19.4%)符合重度抑郁症的《精神疾病诊断与统计手册》第四版标准。在MAAS上报告对胎儿有高度依恋的母亲所报告的抑郁症状严重程度较低(rho=-0.33,p<.0001);在DAS上报告人际关系不满意的母亲所认可的抑郁严重程度较高(rho=-0.21,p=.02)。产科风险的严重程度与抑郁无关,但一种并发症,即宫颈机能不全,与抑郁症状水平呈正相关。
研究结果表明,具有严重产科风险的女性中重度抑郁症的患病率高于低风险妊娠样本中的报告率,这表明需要进行常规的抑郁筛查以识别那些需要治疗的人。报告有强烈母婴依恋和更高关系满意度的母亲所报告的抑郁症状较少。