Kim Chan-Hee, Park Ji-Won, Ha Nam-Chul, Kang Hee Jung, Lee Bok Luel
National Research Laboratory of Defense Proteins, College of Pharmacy, Pusan National University, Busan, Korea.
BMB Rep. 2008 Feb 29;41(2):93-101. doi: 10.5483/bmbrep.2008.41.2.093.
The major cell wall components of bacteria are lipopolysaccharide, peptidoglycan, and teichoic acid. These molecules are known to trigger strong innate immune responses in the host. The molecular mechanisms by which the host recognizes the peptidoglycan of Gram-positive bacteria and amplifies this peptidoglycan recognition signals to mount an immune response remain largely unclear. Recent, elegant genetic and biochemical studies are revealing details of the molecular recognition mechanism and the signalling pathways triggered by bacterial peptidoglycan. Here we review recent progress in elucidating the molecular details of peptidoglycan recognition and its signalling pathways in insects. We also attempt to evaluate the importance of this issue for understanding innate immunity.
细菌的主要细胞壁成分是脂多糖、肽聚糖和磷壁酸。已知这些分子会在宿主体内引发强烈的先天性免疫反应。宿主识别革兰氏阳性菌肽聚糖并放大这种肽聚糖识别信号以引发免疫反应的分子机制在很大程度上仍不清楚。最近，出色的遗传学和生物化学研究正在揭示细菌肽聚糖触发的分子识别机制和信号通路的细节。在此，我们综述了在阐明昆虫中肽聚糖识别及其信号通路的分子细节方面的最新进展。我们还试图评估这个问题对于理解先天性免疫的重要性。
