Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Centre for Global Health, Zhejiang University School of Medicine, Hangzhou, China.
Aliment Pharmacol Ther. 2023 Feb;57(4):399-408. doi: 10.1111/apt.17392. Epub 2023 Jan 16.
Evidence for antioxidants, minerals and vitamins in relation to the risk of Crohn's disease (CD) and ulcerative colitis (UC) is limited and inconsistent. This mendelian randomization (MR) study aimed to examine the causal associations of circulating levels of antioxidants, minerals and vitamins with CD and UC.
Single-nucleotide polymorphisms associated with antioxidants (beta-carotene, lycopene and uric acid), minerals (copper, calcium, iron, magnesium, phosphorus, zinc and selenium), and vitamins (folate, vitamins A, B6, B12, C, D, E and K1) were employed as instrumental variables. Genetic associations with CD and UC were extracted from the UK Biobank, the FinnGen study and the International Inflammatory Bowel Disease Genetics Consortium. The inverse variance weighted method and sensitivity analyses were performed.
Genetically predicted higher lycopene (OR = 0.94, 95% CI: 0.91-0.97), vitamins D (OR = 0.65, 95% CI: 0.54-0.79) and K1 (OR = 0.93, 95% CI: 0.90-0.97) levels were inversely associated with CD risk, whereas genetically predicted higher magnesium (OR = 1.53, 95% CI: 1.23-1.90) levels were positively associated with CD risk. Higher levels of genetically predicted lycopene (OR = 0.91, 95% CI: 0.88-0.95), phosphorus (OR = 0.69, 95% CI: 0.58-0.82), selenium (OR = 0.91, 95% CI: 0.85-0.97), zinc (OR = 0.91, 95% CI: 0.89-0.94), folate (OR = 0.71, 95% CI: 0.56-0.92) and vitamin E (OR = 0.78, 95% CI: 0.69-0.88) were associated with reduced UC risk, whereas genetically predicted high levels of calcium (OR = 1.46, 95% CI: 1.22-1.76) and magnesium (OR = 1.24, 95% CI: 1.03-1.49) were associated with increased risk of UC.
Our study provided evidence that circulating levels of antioxidants, minerals and vitamins might be causally linked to the development of IBD.
关于抗氧化剂、矿物质和维生素与克罗恩病（CD）和溃疡性结肠炎（UC）风险的关系，证据有限且不一致。本孟德尔随机化（MR）研究旨在探讨循环抗氧化剂、矿物质和维生素水平与 CD 和 UC 的因果关系。
使用与抗氧化剂（β-胡萝卜素、番茄红素和尿酸）、矿物质（铜、钙、铁、镁、磷、锌和硒）和维生素（叶酸、维生素 A、B6、B12、C、D、E 和 K1）相关的单核苷酸多态性作为工具变量。从英国生物库、芬兰基因研究和国际炎症性肠病遗传联盟中提取与 CD 和 UC 相关的遗传关联。采用逆方差加权法和敏感性分析进行分析。
遗传预测的较高番茄红素（OR=0.94，95%CI：0.91-0.97）、维生素 D（OR=0.65，95%CI：0.54-0.79）和 K1（OR=0.93，95%CI：0.90-0.97）水平与 CD 风险呈负相关，而遗传预测的较高镁（OR=1.53，95%CI：1.23-1.90）水平与 CD 风险呈正相关。较高的遗传预测番茄红素（OR=0.91，95%CI：0.88-0.95）、磷（OR=0.69，95%CI：0.58-0.82）、硒（OR=0.91，95%CI：0.85-0.97）、锌（OR=0.91，95%CI：0.89-0.94）、叶酸（OR=0.71，95%CI：0.56-0.92）和维生素 E（OR=0.78，95%CI：0.69-0.88）水平与 UC 风险降低相关，而遗传预测的较高钙（OR=1.46，95%CI：1.22-1.76）和镁（OR=1.24，95%CI：1.03-1.49）水平与 UC 风险增加相关。
本研究提供的证据表明，抗氧化剂、矿物质和维生素的循环水平可能与 IBD 的发生有因果关系。
