曲古抑菌素（U-63,366F）在智利对厌氧菌及需氧革兰氏阳性球菌的体外抗菌活性

In vitro antibacterial activity of trospectomycin (U-63,366F) against anaerobic bacteria and aerobic gram-positive cocci in Chile.

作者信息

Montiel F, Kaltwasser G, Pinto M E, Lam M

机构信息

Laboratorio de Microbiología Clínica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago.

出版信息

Diagn Microbiol Infect Dis. 1991 May-Jun;14(3):259-64. doi: 10.1016/0732-8893(91)90040-m.

DOI:10.1016/0732-8893(91)90040-m

PMID:1832369

Abstract

The in vitro activity of trospectomycin sulfate was compared with those of several antimicrobials, against 301 anaerobic bacteria and 613 aerobic Gram-positive cocci. Trospectomycin was about 4- to 32-fold more active than was spectinomycin. Trospectomycin exhibited consistently good activity against all Bacteroides fragilis group isolates, except Bacteroides vulgatus, and against all other anaerobes comparable or higher to that of clindamycin. The trospectomycin's activity was most similar to that of vancomycin, even against methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis.

摘要

将硫酸曲古抑菌素的体外活性与几种抗菌药物的活性进行了比较，受试对象为301株厌氧菌和613株需氧革兰氏阳性球菌。曲古抑菌素的活性比壮观霉素高约4至32倍。除普通拟杆菌外，曲古抑菌素对所有脆弱拟杆菌属菌株均表现出持续良好的活性，对所有其他厌氧菌的活性与克林霉素相当或更高。曲古抑菌素的活性与万古霉素最为相似，即使是对耐甲氧西林金黄色葡萄球菌和耐甲氧西林表皮葡萄球菌也是如此。