曲古霉素对脆弱拟杆菌及其他拟杆菌属菌种的活性。
Activity of trospectomycin against Bacteroides fragilis and other Bacteroides species.
作者信息
Jacobus N V, Tally F P
机构信息
Department of Pathology, New England Medical Center Hospitals, Boston, Massachusetts 02111.
出版信息
Antimicrob Agents Chemother. 1988 Apr;32(4):584-6. doi: 10.1128/AAC.32.4.584.
Abstract
The in vitro activity of trospectomycin (U-63366; 6'-n-propyl spectinomycin pentahydrate sulfate) was evaluated against 189 clinical isolates of the Bacteroides fragilis group and 65 Bacteroides species isolates. At less than or equal to 8 micrograms/ml, the activity of trospectomycin compared favorably with those of clindamycin and cefoxitin against B. fragilis, Bacteroides distasonis, and Bacteroides vulgatus, and there was no cross resistance to these three drugs among the strains of the B. fragilis group. All the Bacteroides species were susceptible to trospectomycin. The results of this in vitro study indicate that trospectomycin possesses excellent activity against Bacteroides species.
摘要
对曲古霉素（U - 63366；6'-正丙基壮观霉素五水合硫酸盐）的体外活性进行了评估，受试对象为189株脆弱拟杆菌属临床分离株和65株拟杆菌属分离株。在浓度小于或等于8微克/毫升时，曲古霉素对脆弱拟杆菌、狄氏拟杆菌和普通拟杆菌的活性与克林霉素和头孢西丁相当，且脆弱拟杆菌属菌株对这三种药物不存在交叉耐药性。所有拟杆菌属菌株均对曲古霉素敏感。这项体外研究结果表明，曲古霉素对拟杆菌属菌株具有优异的活性。
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