Chouhan Raghuraj Singh, Horvat Milena, Ahmed Jahangeer, Alhokbany Norah, Alshehri Saad M, Gandhi Sonu
Department of Environmental Sciences, Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia.
Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Cancers (Basel). 2021 May 5;13(9):2213. doi: 10.3390/cancers13092213.
Magnetic nanoparticles gained considerable attention in last few years due to their remarkable properties. Superparamaganetism, non-toxicity, biocompatibility, chemical inertness, and environmental friendliness are some of the properties that make iron oxide nanoparticles (IONPs) an ideal choice for biomedical applications. Along with being easily tuneable and a tailored surface for conjugation of IONPs, their physio-chemical and biological properties can also be varied by modifying the basic parameters for synthesis that enhances the additional possibilities for designing novel magnetic nanomaterial for theranostic applications. This review highlights the synthesis, surface modification, and different applications of IONPs for diagnosis, imaging, and therapy. Furthermore, it also represents the recent report on the application of IONPs as enzyme mimetic compounds and a contrasting agent, and its significance in the field as an anticancer and antimicrobial agent.
近年来，磁性纳米颗粒因其卓越的性能而备受关注。超顺磁性、无毒、生物相容性、化学惰性和环境友好性等特性使氧化铁纳米颗粒（IONPs）成为生物医学应用的理想选择。除了易于调节以及为IONPs的共轭提供定制表面外，通过改变合成的基本参数，还可以改变其物理化学和生物学特性，这增加了设计用于治疗诊断应用的新型磁性纳米材料的可能性。本综述重点介绍了IONPs在诊断、成像和治疗方面的合成、表面修饰及不同应用。此外，还介绍了IONPs作为酶模拟化合物和造影剂的最新应用报告，以及其在抗癌和抗菌领域的重要意义。
