纳米技术及其在成像和药物递送中的应用（综述）。
Nanotechnology and its use in imaging and drug delivery (Review).
作者信息
Sim Serjay, Wong Nyet Kui
机构信息
School of Health Sciences, Division of Applied Biomedical Sciences and Biotechnology, International Medical University, Kuala Lumpur 57000, Malaysia.
出版信息
Biomed Rep. 2021 May;14(5):42. doi: 10.3892/br.2021.1418. Epub 2021 Mar 5.
Abstract
Nanotechnology is the exploitation of the unique properties of materials at the nanoscale. Nanotechnology has gained popularity in several industries, as it offers better built and smarter products. The application of nanotechnology in medicine and healthcare is referred to as nanomedicine, and it has been used to combat some of the most common diseases, including cardiovascular diseases and cancer. The present review provides an overview of the recent advances of nanotechnology in the aspects of imaging and drug delivery.
摘要
纳米技术是对纳米尺度材料独特性质的开发利用。纳米技术已在多个行业中受到欢迎，因为它能提供质量更好、更智能的产品。纳米技术在医学和医疗保健领域的应用被称为纳米医学，它已被用于对抗一些最常见的疾病，包括心血管疾病和癌症。本综述概述了纳米技术在成像和药物递送方面的最新进展。
相似文献
1
Nanotechnology and its use in imaging and drug delivery (Review).纳米技术及其在成像和药物递送中的应用（综述）。
Biomed Rep. 2021 May;14(5):42. doi: 10.3892/br.2021.1418. Epub 2021 Mar 5.
2
Nanotechnology for nanomedicine and delivery of drugs.用于纳米医学和药物递送的纳米技术。
Curr Pharm Des. 2008;14(22):2184-200. doi: 10.2174/138161208785740180.
3
Unique benefits of nanotechnology to drug delivery and diagnostics.纳米技术在药物递送和诊断方面的独特优势。
Methods Mol Biol. 2011;697:3-8. doi: 10.1007/978-1-60327-198-1_1.
4
Nanotechnology and nanomedicine: going small means aiming big.纳米技术与纳米医学：小处着手，志在千里。
Curr Pharm Des. 2010 Jun;16(16):1882-92. doi: 10.2174/138161210791208992.
5
Recent Interventions for Nanotechnology Based Drug Products: Insights into the Regulatory Aspects.基于纳米技术的药物产品的最新干预措施：对监管方面的深入了解。
Curr Pharm Des. 2018;24(43):5219-5228. doi: 10.2174/1381612825666190117094250.
6
Nanomedicines: addressing the scientific and regulatory gap.纳米药物：解决科学和监管差距。
Ann N Y Acad Sci. 2014 Apr;1313:35-56. doi: 10.1111/nyas.12403. Epub 2014 Mar 27.
7
Nanotechnology: the scope and potential applications in orthopedic surgery.纳米技术：在骨科手术中的范围及潜在应用
Eur J Orthop Surg Traumatol. 2018 Oct;28(7):1257-1260. doi: 10.1007/s00590-018-2193-z. Epub 2018 Mar 30.
8
Tiny technology proves big: a challenge at engineering, medicine and pharmaceutical sciences interface.微小技术彰显强大力量：工程学、医学与制药科学交叉领域的一项挑战
Crit Rev Ther Drug Carrier Syst. 2014;31(1):1-47. doi: 10.1615/critrevtherdrugcarriersyst.2013007914.
9
Green nanotechnology-based drug delivery systems for osteogenic disorders.基于绿色纳米技术的骨病药物传递系统。
Expert Opin Drug Deliv. 2020 Mar;17(3):341-356. doi: 10.1080/17425247.2020.1727441. Epub 2020 Feb 17.
10
Nanotechnology and glaucoma: a review of the potential implications of glaucoma nanomedicine.纳米技术与青光眼：青光眼纳米医学潜在影响的综述。
Br J Ophthalmol. 2014 Apr;98(4):427-31. doi: 10.1136/bjophthalmol-2013-304028. Epub 2013 Nov 18.
引用本文的文献
1
Nanoparticle-assisted strategies in mass spectrometry-based metabolite analysis: recent advances across analytical workflow.基于质谱的代谢物分析中的纳米颗粒辅助策略：分析工作流程的最新进展
Mikrochim Acta. 2025 Aug 23;192(9):618. doi: 10.1007/s00604-025-07473-7.
2
Advances in multimodal imaging techniques in nanomedicine: enhancing drug delivery precision.纳米医学中多模态成像技术的进展：提高药物递送精度
RSC Adv. 2025 Jul 30;15(33):27187-27209. doi: 10.1039/d5ra03255e. eCollection 2025 Jul 25.
3
Novel (1S,3R)-RSL3-Encapsulated Polyunsaturated Fatty Acid Rich Liposomes Sensitise Multiple Myeloma Cells to Ferroptosis-Mediated Cell Death.新型（1S,3R）-RSL3包裹的富含多不饱和脂肪酸的脂质体使多发性骨髓瘤细胞对铁死亡介导的细胞死亡敏感。
Int J Mol Sci. 2025 Jul 9;26(14):6579. doi: 10.3390/ijms26146579.
4
The Application of Functional Nanomaterials-Based Electrochemical Biosensors in Detecting Cancer Biomarkers: A Review.基于功能纳米材料的电化学生物传感器在癌症生物标志物检测中的应用：综述
Molecules. 2025 Jun 23;30(13):2708. doi: 10.3390/molecules30132708.
5
Nanotechnology in dentistry: Bridging science and practice.牙科中的纳米技术：连接科学与实践。
Bioinformation. 2025 Mar 31;21(3):522-528. doi: 10.6026/973206300210522. eCollection 2025.
6
Intelligent deep learning model for targeted cancer drug delivery.用于靶向癌症药物递送的智能深度学习模型。
Sci Rep. 2025 May 30;15(1):19068. doi: 10.1038/s41598-025-96149-6.
7
Revolutionizing Retinal Therapy: The Role of Nanoparticle Drug Carriers in Managing Vascular Retinal Disorders.视网膜治疗的变革：纳米颗粒药物载体在治疗视网膜血管疾病中的作用
Clin Ophthalmol. 2025 May 15;19:1565-1582. doi: 10.2147/OPTH.S503273. eCollection 2025.
8
Emerging nanotechnologies and their role in early ovarian cancer detection, diagnosis and interventions.新兴纳米技术及其在早期卵巢癌检测、诊断和干预中的作用。
J Ovarian Res. 2025 May 7;18(1):96. doi: 10.1186/s13048-025-01678-3.
9
Cellular Signaling at the Nano-Bio Interface: Spotlighting Membrane Curvature.纳米生物界面处的细胞信号传导：聚焦膜曲率
Annu Rev Phys Chem. 2025 Apr;76(1):251-277. doi: 10.1146/annurev-physchem-090722-021151.
10
Advanced Strategies in Enhancing the Hepatoprotective Efficacy of Natural Products: Integrating Nanotechnology, Genomics, and Mechanistic Insights.提高天然产物肝脏保护功效的先进策略：整合纳米技术、基因组学和作用机制见解
ACS Biomater Sci Eng. 2025 May 12;11(5):2528-2549. doi: 10.1021/acsbiomaterials.5c00004. Epub 2025 Apr 11.
本文引用的文献
1
Aortic plaque-targeted andrographolide delivery with oxidation-sensitive micelle effectively treats atherosclerosis via simultaneous ROS capture and anti-inflammation.载药氧化敏感胶束实现靶向主动脉斑块给药，通过同时捕获 ROS 和抗炎治疗动脉粥样硬化。
Nanomedicine. 2018 Oct;14(7):2215-2226. doi: 10.1016/j.nano.2018.06.010. Epub 2018 Jun 30.
2
Cyclic RGD functionalized liposomes encapsulating urokinase for thrombolysis.载尿激酶环 RGD 功能化脂质体用于溶栓。
Acta Biomater. 2018 Apr 1;70:227-236. doi: 10.1016/j.actbio.2018.01.038. Epub 2018 Feb 9.
3
Anti-inflammatory Nanomedicine for Cardiovascular Disease.用于心血管疾病的抗炎纳米药物
Front Cardiovasc Med. 2017 Dec 22;4:87. doi: 10.3389/fcvm.2017.00087. eCollection 2017.
4
Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy.树状高分子作为用于癌症治疗中核酸和药物传递的纳米载体。
Molecules. 2017 Aug 23;22(9):1401. doi: 10.3390/molecules22091401.
5
Near-Infrared Responsive Gold-Layersome Nanoshells.近红外响应金层状纳米壳
Langmuir. 2017 May 30;33(21):5321-5327. doi: 10.1021/acs.langmuir.7b01273. Epub 2017 May 19.
6
Liposomal Formulations in Clinical Use: An Updated Review.临床应用中的脂质体制剂：最新综述。
Pharmaceutics. 2017 Mar 27;9(2):12. doi: 10.3390/pharmaceutics9020012.
7
Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date.基于纳米颗粒的药物：对美国食品药品监督管理局（FDA）批准的材料及迄今临床试验的综述。
Pharm Res. 2016 Oct;33(10):2373-87. doi: 10.1007/s11095-016-1958-5. Epub 2016 Jun 14.
8
The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction.纳米颗粒大小对体内药代动力学和细胞相互作用的影响。
Nanomedicine (Lond). 2016 Mar;11(6):673-92. doi: 10.2217/nnm.16.5. Epub 2016 Mar 22.
9
Therapeutic Efficacy of an ω-3-Fatty Acid-Containing 17-β Estradiol Nano-Delivery System against Experimental Atherosclerosis.含ω-3脂肪酸的17-β雌二醇纳米递送系统对实验性动脉粥样硬化的治疗效果
PLoS One. 2016 Feb 3;11(2):e0147337. doi: 10.1371/journal.pone.0147337. eCollection 2016.
10
Applications of gold nanoparticles in optical biosensors.金纳米粒子在光学生物传感器中的应用。
J Biomed Nanotechnol. 2014 Oct;10(10):2700-21. doi: 10.1166/jbn.2014.1987.
Zotero 插件