Yang Jaemoon, Lee Jaewon, Kang Jinyoung, Lee Kwangyeol, Suh Jin-Suck, Yoon Ho-Geun, Huh Yong-Min, Haam Seungjoo
Department of Chemical Engineering, Yonsei University, Seoul 120-749, Korea, Graduate Program for Nanomedical Science, Yonsei University, Seoul 120-752, Korea.
Langmuir. 2008 Apr 1;24(7):3417-21. doi: 10.1021/la701688t. Epub 2008 Mar 7.
Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe(3)O(4) nanocrystals, as templates. The core cavity was obtained by removal of Fe(3)O(4) phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.
以由多个Fe(3)O(4)纳米晶体组成的二氧化硅包覆磁性组件为模板，合成了用于药物递送载体的新型中空二氧化硅纳米颗粒（HSNPs）。通过用盐酸去除Fe(3)O(4)相并随后在高温下煅烧获得核心腔。HSNPs用胺进行修饰以引入正表面电荷，并进一步聚乙二醇化以增加在水性介质中的溶解度。将阿霉素作为模型药物负载到HSNPs中，并证明了HSNPs有显著的持续药物释放。
