Kwee Thomas C, Kwee Robert M, Verdonck Leo F, Bierings Marc B, Nievelstein Rutger A J
Department of Radiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Br J Haematol. 2008 Apr;141(1):60-8. doi: 10.1111/j.1365-2141.2008.07020.x.
This study systematically reviewed the published data regarding the sensitivity of magnetic resonance imaging (MRI) compared with bone marrow biopsy as reference standard for the detection of bone marrow involvement in patients with malignant lymphoma. A systematic search for relevant studies was performed of the PubMed/MEDLINE and Embase databases. Two reviewers independently assessed the methodological quality of each study and the sensitivity of the included studies was calculated. The 11 included studies had moderate methodological quality. Sensitivity of MRI for the detection of bone marrow involvement ranged from 50% to 100%, with a median of 100%. MRI is probably sufficiently sensitive to rule out bone marrow involvement in patients with malignant lymphoma. However, a well-designed study with a large sample size is needed to confirm current results.
本研究系统回顾了已发表的数据，这些数据是关于将磁共振成像（MRI）与骨髓活检作为检测恶性淋巴瘤患者骨髓受累的参考标准相比较时的敏感性。对PubMed/MEDLINE和Embase数据库进行了相关研究的系统检索。两名评审员独立评估每项研究的方法学质量，并计算纳入研究的敏感性。纳入的11项研究方法学质量中等。MRI检测骨髓受累的敏感性范围为50%至100%，中位数为100%。MRI可能有足够的敏感性来排除恶性淋巴瘤患者的骨髓受累。然而，需要一项设计良好且样本量较大的研究来证实当前结果。
