Ignatova M, Markova N, Manolova N, Rashkov I
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev 103A, 1113 Sofia, Bulgaria.
J Biomater Sci Polym Ed. 2008;19(3):373-86. doi: 10.1163/156856208783721056.
Photo-cross-linked poly(vinyl pyrrolidone) (PVP) and poly(ethylene oxide)(PEO)/PVP electrospun nanofibrous mats containing complex-bound iodine have been studied. FT-IR spectroscopy analyses have proved that coordination of molecular iodine with carbonyl group and nitrogen atom of pyrrolidone rings of the PVP chains has taken place. The distribution of iodine along the fibers is uniform as revealed by X-ray mapping. The microbiological tests have demonstrated that the iodine complex-containing electrospun mats are highly effective against the Gram-positive bacterium Staphylococcus aureus, the Gram-negative bacterium Escherichia coli and the fungus Candida albicans. Comparison with iodine complex-containing films has shown that the iodine complex-containing nanofibers exhibit a higher killing rate than the films against bacteria E. coli. SEM observations showed that PVP-iodine nanofibrous mats inhibit the adhesion of bacteria S. aureus. These characteristic features make the electrospun iodine-containing nanofibers good candidates for wound-dressing materials.
对含有络合碘的光交联聚（乙烯基吡咯烷酮）（PVP）和聚环氧乙烷（PEO）/PVP电纺纳米纤维垫进行了研究。傅里叶变换红外光谱分析证明，分子碘与PVP链中吡咯烷酮环的羰基和氮原子发生了配位作用。X射线映射显示，碘沿纤维的分布是均匀的。微生物测试表明，含碘络合物的电纺垫对革兰氏阳性菌金黄色葡萄球菌、革兰氏阴性菌大肠杆菌和真菌白色念珠菌具有高效杀灭作用。与含碘络合物的薄膜相比，含碘络合物的纳米纤维对大肠杆菌的杀灭率高于薄膜。扫描电子显微镜观察表明，PVP-碘纳米纤维垫可抑制金黄色葡萄球菌的黏附。这些特性使电纺含碘纳米纤维成为伤口敷料材料的理想选择。
