Wackermann Jirí, Wittmann Marc, Hasler Felix, Vollenweider Franz X
Department of Empirical and Analytical Psychophysics, Institute for Frontier Areas of Psychology and Mental Health, Wilhelmstrasse 3a, D-79098 Freiburg i. Br., Germany.
Neurosci Lett. 2008 Apr 11;435(1):51-5. doi: 10.1016/j.neulet.2008.02.006. Epub 2008 Feb 9.
Action of a hallucinogenic substance, psilocybin, on internal time representation was investigated in two double-blind, placebo-controlled studies: Experiment 1 with 12 subjects and graded doses, and Experiment 2 with 9 subjects and a very low dose. The task consisted in repeated reproductions of time intervals in the range from 1.5 to 5s. The effects were assessed by parameter kappa of the 'dual klepsydra' model of internal time representation, fitted to individual response data and intra-individually normalized with respect to initial values. The estimates kappa were in the same order of magnitude as in earlier studies. In both experiments, kappa was significantly increased by psilocybin at 90 min from the drug intake, indicating a higher loss rate of the internal duration representation. These findings are tentatively linked to qualitative alterations of subjective time in altered states of consciousness.
在两项双盲、安慰剂对照研究中，对致幻物质裸盖菇素对内部时间表征的作用进行了研究：实验1有12名受试者，采用分级剂量；实验2有9名受试者，采用极低剂量。任务包括重复再现1.5至5秒范围内的时间间隔。通过内部时间表征的“双漏壶”模型的kappa参数评估效果，该模型拟合个体反应数据并相对于初始值进行个体内归一化。估计的kappa与早期研究中的量级相同。在两个实验中，服用裸盖菇素90分钟后，kappa均显著增加，表明内部持续时间表征的损失率更高。这些发现初步与意识改变状态下主观时间的质性改变相关联。
