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The legacy of HfrH: mutations in the two-component system CreBC are responsible for the unusual phenotype of an Escherichia coli arcA mutant.高频重组菌HfrH的遗传特性：双组分系统CreBC中的突变导致大肠杆菌arcA突变体出现异常表型。
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Microbial Cell Factories à : Elimination of Global Regulators Cra and ArcA Generates Metabolic Backgrounds Suitable for the Synthesis of Bioproducts in Escherichia coli.微生物细胞工厂：消除全局调控因子 Cra 和 ArcA 可生成适合大肠杆菌生物制品合成的代谢背景。
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Pseudomonas 2.0: genetic upgrading of P. putida KT2440 as an enhanced host for heterologous gene expression.假单胞菌2.0：恶臭假单胞菌KT2440的基因升级作为异源基因表达的强化宿主
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Manipulation of the anoxic metabolism in Escherichia coli by ArcB deletion variants in the ArcBA two-component system.ArcB 缺失变体在 ArcBA 双组分系统中对大肠杆菌缺氧代谢的调控。
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本文引用的文献

1
Escherichia coli arcA mutants: metabolic profile characterization of microaerobic cultures using glycerol as a carbon source.大肠杆菌arcA突变体：以甘油作为碳源的微需氧培养物的代谢谱特征分析
J Mol Microbiol Biotechnol. 2008;15(1):48-54. doi: 10.1159/000111992. Epub 2008 Mar 14.
2
dye (arc) Mutants: insights into an unexplained phenotype and its suppression by the synthesis of poly (3-hydroxybutyrate) in Escherichia coli recombinants.染料（弧）突变体：对一种无法解释的表型及其在大肠杆菌重组体中通过聚（3-羟基丁酸酯）合成而被抑制的深入了解。
FEMS Microbiol Lett. 2006 May;258(1):55-60. doi: 10.1111/j.1574-6968.2006.00196.x.
3
Poly(3-hydroxybutyrate) synthesis by recombinant Escherichia coli arcA mutants in microaerobiosis.重组大肠杆菌arcA突变体在微需氧条件下合成聚（3-羟基丁酸酯）
Appl Environ Microbiol. 2006 Apr;72(4):2614-20. doi: 10.1128/AEM.72.4.2614-2620.2006.
4
Effect of oxygen, and ArcA and FNR regulators on the expression of genes related to the electron transfer chain and the TCA cycle in Escherichia coli.氧气、ArcA和FNR调节因子对大肠杆菌中与电子传递链和三羧酸循环相关基因表达的影响。
Metab Eng. 2005 Sep-Nov;7(5-6):364-74. doi: 10.1016/j.ymben.2005.07.001. Epub 2005 Sep 2.
5
Characterization of the acetate-producing pathways in Escherichia coli.大肠杆菌中乙酸盐生成途径的表征
Biotechnol Prog. 2005 Jul-Aug;21(4):1062-7. doi: 10.1021/bp050073s.
6
Global gene expression profiling in Escherichia coli K12: effects of oxygen availability and ArcA.大肠杆菌K12中的全基因组表达谱分析：氧可用性和ArcA的影响
J Biol Chem. 2005 Apr 15;280(15):15084-96. doi: 10.1074/jbc.M414030200. Epub 2005 Feb 7.
7
Effect of oxygen on the Escherichia coli ArcA and FNR regulation systems and metabolic responses.氧气对大肠杆菌ArcA和FNR调控系统及代谢反应的影响。
Biotechnol Bioeng. 2005 Mar 5;89(5):556-64. doi: 10.1002/bit.20381.
8
Genome-wide expression analysis indicates that FNR of Escherichia coli K-12 regulates a large number of genes of unknown function.全基因组表达分析表明，大肠杆菌K-12的FNR调控大量功能未知的基因。
J Bacteriol. 2005 Feb;187(3):1135-60. doi: 10.1128/JB.187.3.1135-1160.2005.
9
Probing the ArcA-P modulon of Escherichia coli by whole genome transcriptional analysis and sequence recognition profiling.通过全基因组转录分析和序列识别谱分析探究大肠杆菌的ArcA-P调节子
J Biol Chem. 2004 Mar 26;279(13):12588-97. doi: 10.1074/jbc.M313454200. Epub 2004 Jan 7.
10
Requirement of ArcA for redox regulation in Escherichia coli under microaerobic but not anaerobic or aerobic conditions.在微需氧而非厌氧或需氧条件下，大肠杆菌中ArcA对氧化还原调节的需求。
J Bacteriol. 2003 Jan;185(1):204-9. doi: 10.1128/JB.185.1.204-209.2003.

高频重组菌HfrH的遗传特性：双组分系统CreBC中的突变导致大肠杆菌arcA突变体出现异常表型。

The legacy of HfrH: mutations in the two-component system CreBC are responsible for the unusual phenotype of an Escherichia coli arcA mutant.

作者信息

Nikel Pablo I, de Almeida Alejandra, Pettinari M Julia, Méndez Beatriz S

机构信息

Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.

出版信息

J Bacteriol. 2008 May;190(9):3404-7. doi: 10.1128/JB.00040-08. Epub 2008 Mar 7.

DOI:10.1128/JB.00040-08
PMID:18326580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2347385/
Abstract

Strains derived from HfrH carrying the arcA2 null mutation exhibit a higher respiratory rate, enhanced glucose consumption, and a more-reduced intracellular redox state than arcA deletion mutants of a different lineage. The phenotype of the arcA2 mutants was due to the presence of a creC constitutive mutation introduced by P1 transduction.

摘要

携带arcA2无效突变的源自HfrH的菌株比不同谱系的arcA缺失突变体表现出更高的呼吸速率、增强的葡萄糖消耗和更低的细胞内氧化还原状态。arcA2突变体的表型是由于通过P1转导引入的creC组成型突变的存在。