Salom David, Diaz-Llopis Manuel, García-Delpech Salvador, Udaondo Patricia, Sancho-Tello Maria, Romero F Javier
Department of Ophthalmology, University General Hospital of Valencia, Valencia, Spain.
Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3499-502. doi: 10.1167/iovs.07-1168. Epub 2008 Mar 7.
To determine the level of vascular endothelial growth factor A (VEGF-A) in aqueous humors of patients with retinitis pigmentosa (RP).
A prospective, comparative control study. Aqueous humor was collected from 16 eyes of 16 patients with RP. The level of VEGF-A was determined with a commercially available enzyme-linked immunosorbent assay kit. The control group comprised 16 aqueous samples from 16 patients about to undergo cataract surgery and without any other ocular or systemic diseases.
The concentration of VEGF-A in aqueous humor was markedly lower in patients with RP than in control subjects (Mann-Whitney U test, P < 0.001). The level of VEGF-A was 94.9 +/- 99.8 (mean +/- SD) pg/mL in eyes with RP and 336.5 +/- 116.8 pg/mL in the eyes of the control group.
In patients with RP, the concentration of VEGF-A in aqueous humors is lower than in non-RP subjects. The lack of angiogenic actions attributed to VEGF-A may explain some of the clinical manifestations of this disease, such as narrowing and fibrotic degeneration of retinal blood vessels.
测定视网膜色素变性（RP）患者房水中血管内皮生长因子A（VEGF-A）的水平。
一项前瞻性、对照研究。从16例RP患者的16只眼中采集房水。使用市售酶联免疫吸附测定试剂盒测定VEGF-A的水平。对照组包括16例即将接受白内障手术且无任何其他眼部或全身性疾病的患者的16份房水样本。
RP患者房水中VEGF-A的浓度明显低于对照组（曼-惠特尼U检验，P<0.001）。RP患者眼中VEGF-A的水平为94.9±99.8（平均值±标准差）pg/mL，对照组患者眼中为336.5±116.8 pg/mL。
RP患者房水中VEGF-A的浓度低于非RP患者。VEGF-A缺乏血管生成作用可能解释了该疾病的一些临床表现，如视网膜血管变窄和纤维化变性。
