Department of Ophthalmology, La Fe University Hospital of Valencia, Valencia, Spain. david.salom@ yahoo.com
Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3157-61. doi: 10.1167/iovs.09-4390. Epub 2010 Jan 6.
To determine the level of hepatocyte growth factor (HGF) in the aqueous humor of patients with retinitis pigmentosa (RP).
This was a prospective, comparative control study. Aqueous humor samples were collected from the eyes of 15 RP patients. The level of HGF was determined with a commercially available enzyme-linked immunoabsorbent assay kit. The control group was composed of aqueous samples from 15 patients about to undergo cataract surgery with no other ocular or systemic diseases.
The concentration of HGF was markedly higher in the aqueous humor of the patients with RP than in that of the control subjects (Mann-Whitney U test, P < 0.001). The level of HGF was 958.75 +/- 271.52 (mean +/- SD) pg/mL in the eyes of the RP patients and 403.52 +/- 116.27 pg/mL in eyes of the control group.
The concentration of HGF in aqueous humor is higher among patients with RP than in non-RP subjects. This finding provides new evidence that should be taken in account when considering HGF as a neuroprotective treatment for patients with RP.
测定色素性视网膜炎（RP）患者房水中肝细胞生长因子（HGF）的水平。
这是一项前瞻性、对照研究。从 15 例 RP 患者的眼中采集房水样本。使用市售的酶联免疫吸附测定试剂盒测定 HGF 水平。对照组由 15 例即将接受白内障手术且无其他眼部或全身疾病的患者的房水样本组成。
RP 患者房水中 HGF 的浓度明显高于对照组（Mann-Whitney U 检验，P < 0.001）。RP 患者眼内 HGF 的水平为 958.75 +/- 271.52（均数 +/- 标准差）pg/mL，对照组眼内 HGF 的水平为 403.52 +/- 116.27 pg/mL。
RP 患者房水中 HGF 的浓度高于非 RP 患者。这一发现为将 HGF 作为 RP 患者的神经保护治疗提供了新的证据，值得进一步研究。
