含糖饮料摄入与骨骼健康：系统评价和荟萃分析。
Sugar-sweetened beverage consumption and bone health: a systematic review and meta-analysis.
机构信息
Department of Gerontology (AgeTech-Service Convergence Major), Kyung Hee University, Yongin, Republic of Korea.
Department of Medical Nutrition (AgeTech-Service Convergence Major), Graduate School of East-West Medical Science, Kyung Hee University, Giheung-gu, Yongin-si, Gyeonggi-do, 17104, Republic of Korea.
出版信息
Nutr J. 2021 May 5;20(1):41. doi: 10.1186/s12937-021-00698-1.
BACKGROUND
Current evidence demonstrate that sugar-sweetened beverages (SSBs) and bone health are related; however, there has been only a few reviews on the link between SSBs and bone health. A systematic review and meta-analysis was performed to investigate the association between SSBs consumption and bone health in chidren and adults.
METHODS
Relevant studies of SSBs and bone health published up to 15 March 2021 were searched using PubMed, the Web of Science, Cochrane Library, and a reference search. A random-effects meta-analysis was conducted to estimate the standardized mean difference (SMD). Subgroup analyses were performed to identify whether effects were modified by age, sex, measured skeletal sites, type of SSBs, and SSBs intake questionnaire.
RESULTS
Twenty-six publications including 124,691 participants were selected on the review. The results from this meta-analysis showed a significant inverse association between SSBs intake and bone mineral density (BMD) in adults (ES: -0.66, 95% CI: - 1.01, - 0.31, n = 4312). Eighteen of the 20 studies included in the qualitative-only review in children and adults supported the findings from the meta-analysis. When subgroup analysis was performed according to skeletal site, a large effect was found on whole body BMD (ES: -0.97, 95% CI: - 1.54, - 0.40). There was a moderate effect on BMD in females (ES: -0.50, 95% CI: - 0.87, - 0.13). There was a moderate or large effect on BMD in individuals aged under 50 years (under 30 years: ES: -0.57, 95% CI: - 0.97, - 0.17; 30 to 50 years: ES: -1.33, 95% CI: - 1.72, - 0.93). High consumption of carbonated beverages had a moderate effect on BMD (ES: -0.73, 95% CI: - 1.12, - 0.35).
CONCLUSION
The meta-analysis showed that SSBs consumption such as carbonated beverages were inversely related to BMD in adults. Qualitative review supported the results of meta-analysis.
TRIAL REGISTRATION
This review was registered in the PROSPERO database under identifier CRD42020164428 .
背景
目前的证据表明，含糖饮料（SSB）与骨骼健康有关；然而，关于 SSB 与骨骼健康之间的联系，仅有少数综述。本系统评价和荟萃分析旨在调查儿童和成人 SSB 摄入与骨骼健康之间的关系。
方法
截至 2021 年 3 月 15 日，使用 PubMed、Web of Science、Cochrane 图书馆和参考文献搜索，检索有关 SSB 和骨骼健康的相关研究。采用随机效应荟萃分析估计标准化均数差（SMD）。进行亚组分析以确定年龄、性别、测量骨骼部位、SSB 类型和 SSB 摄入量问卷是否会改变效应。
结果
综述共纳入 26 项研究，共纳入 124691 名参与者。荟萃分析结果显示，成人 SSB 摄入量与骨密度（BMD）呈显著负相关（ES：-0.66，95%CI：-1.01，-0.31，n=4312）。20 项定性综述中，有 18 项在儿童和成人中支持荟萃分析的结果。根据骨骼部位进行亚组分析时，发现全身 BMD 存在较大效应（ES：-0.97，95%CI：-1.54，-0.40）。女性 BMD 存在中度效应（ES：-0.50，95%CI：-0.87，-0.13）。50 岁以下个体（30 岁以下：ES：-0.57，95%CI：-0.97，-0.17；30-50 岁：ES：-1.33，95%CI：-1.72，-0.93）BMD 存在中度或较大效应。碳酸饮料的高摄入量对 BMD 有中度影响（ES：-0.73，95%CI：-1.12，-0.35）。
结论
荟萃分析表明，SSB 摄入（如碳酸饮料）与成人 BMD 呈负相关。定性综述支持荟萃分析的结果。
试验注册
本综述在 PROSPERO 数据库中注册，标识符为 CRD42020164428。
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