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硬皮病中血管反应性的调节：雷诺现象的新见解。

Regulation of vascular reactivity in scleroderma: new insights into Raynaud's phenomenon.

作者信息

Flavahan Nicholas A

机构信息

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Ross Research Building R370, 720 Rutland Avenue, Baltimore, MD 21205, USA.

出版信息

Rheum Dis Clin North Am. 2008 Feb;34(1):81-7; vii. doi: 10.1016/j.rdc.2007.12.005.

DOI:10.1016/j.rdc.2007.12.005
PMID:18329534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2336896/
Abstract

Because of the role of the RhoA/Rho kinase (ROCK) pathway in regulating numerous pathologic processes including vasoconstriction, vascular remodeling, and fibrosis, ROCK inhibitors may be especially beneficial in treating Raynaud's phenomenon and scleroderma.

摘要

由于RhoA/Rho激酶（ROCK）通路在调节包括血管收缩、血管重塑和纤维化在内的众多病理过程中发挥作用，ROCK抑制剂在治疗雷诺现象和硬皮病方面可能特别有益。

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本文引用的文献

1
Rho kinase (ROCK) inhibitors.Rho激酶（ROCK）抑制剂。
J Cardiovasc Pharmacol. 2007 Jul;50(1):17-24. doi: 10.1097/FJC.0b013e318070d1bd.
2
Estrogen increases smooth muscle expression of alpha2C-adrenoceptors and cold-induced constriction of cutaneous arteries.雌激素可增加α2C肾上腺素能受体的平滑肌表达以及寒冷诱导的皮肤动脉收缩。
Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1955-61. doi: 10.1152/ajpheart.00306.2007. Epub 2007 Jul 20.
3
Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.α2C肾上腺素能受体在小鼠局部冷却诱导的皮肤血流减少中的作用。
Br J Pharmacol. 2007 Sep;152(1):91-100. doi: 10.1038/sj.bjp.0707380. Epub 2007 Jul 9.
4
Rho kinase-mediated local cold-induced cutaneous vasoconstriction is augmented in aged human skin.Rho激酶介导的局部冷诱导皮肤血管收缩在老年人皮肤中增强。
Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H30-6. doi: 10.1152/ajpheart.00152.2007. Epub 2007 Apr 6.
5
Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.氧气通过增加线粒体衍生的活性氧激活Rho/Rho激酶途径，并诱导人及兔动脉导管中RhoB和ROCK-1的表达：一种维持导管收缩的新认识机制。
Circulation. 2007 Apr 3;115(13):1777-88. doi: 10.1161/CIRCULATIONAHA.106.649566. Epub 2007 Mar 12.
6
Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin.寒冷诱导的皮肤血管收缩在人体皮肤中由Rho激酶在体内介导。
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