Kita Naoko, Mitsushita Junji
Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
Curr Med Chem. 2008;15(7):711-5. doi: 10.2174/092986708783885309.
Despite its clinical importance, the mechanism of preeclampsia is unclear; however, many believe placental pathology might be related to maternal systemic disease. If this is true, a factor which mediates information from the placenta to the maternal circulation can be hypothesized. Among a variety of such reported factors, soluble fms-like tyrosine kinase-1 (sFlt1) will be the focus of this review. The hypoxic placenta, which is commonly found in preeclampsia, produces sFlt1; furthermore, animal experiments suggest its over-expression leads to preeclampsia-like symptoms.
尽管子痫前期具有临床重要性，但其发病机制尚不清楚；然而，许多人认为胎盘病理可能与母体全身性疾病有关。如果这是真的，那么可以推测存在一种将胎盘信息传递至母体循环的因子。在各种已报道的此类因子中，可溶性fms样酪氨酸激酶-1（sFlt1）将成为本综述的重点。子痫前期中常见的缺氧胎盘会产生sFlt1；此外，动物实验表明其过度表达会导致子痫前期样症状。
