Neurology Department, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
Cytokine. 2011 Jan;53(1):66-73. doi: 10.1016/j.cyto.2010.09.003. Epub 2010 Oct 8.
We wanted to assess to what extent concentrations of circulating proteins appear to be developmentally regulated, and to what extent such regulation is influenced by intra-uterine inflammation.
We measured 22 proteins in blood obtained on postnatal days 1, 7, and 14 from 818 children born before the 28th week of gestation for whom we also had information about placenta morphology.
Within the narrow gestational age range of this sample, some protein concentrations increase in blood with increasing gestational age. More commonly, the concentrations of inflammation-related proteins decrease with increasing gestational age. We observed this inverse pattern both in children whose placenta was and was not inflamed. CONCLUSIONS/INFERENCES: Regardless of whether or not the placenta is inflamed, the concentrations of inflammation-related proteins in early blood specimens appear to be developmentally regulated with the most common pattern being a decrease with increasing gestational age.
我们想评估循环蛋白的浓度在多大程度上似乎受到发育调控，以及这种调控在多大程度上受到宫内炎症的影响。
我们测量了 818 名在 28 孕周前出生的儿童在出生后第 1、7 和 14 天的血液中的 22 种蛋白质，这些儿童的胎盘形态也有相关信息。
在这个样本的狭窄胎龄范围内，一些蛋白质的浓度随着胎龄的增加而增加。更常见的是，与炎症相关的蛋白质的浓度随着胎龄的增加而降低。我们在胎盘有或没有炎症的儿童中都观察到了这种相反的模式。
结论/推论：无论胎盘是否有炎症，早期血液样本中与炎症相关的蛋白质的浓度似乎受到发育的调节，最常见的模式是随着胎龄的增加而降低。
