Vaccaro F, Caccavo D, Roumpedaki E, De Vincentis G, Di Gioia C R T, Gallo P, Palange P
Int J Immunopathol Pharmacol. 2008 Jan-Mar;21(1):237-41. doi: 10.1177/039463200802100128.
Dilated cardiomyopathy due to thrombotic microangiopathy has been rarely reported as a clinical manifestation of antiphospholipid syndrome (APS). We describe the case of a 39-year-old woman affected by systemic lupus erythematosus (SLE) and positive antiphospholipid antibodies (aPL) who presented with orthopnea and peripheral oedema. Diagnosis of dilated cardiomyopathy due to myocardial thrombotic microangiopathy was made and treatment with anticoagulants prevented the worsening of the clinical condition. Interestingly, at variance with other cases, our patient showed no extracardiac signs of APS. The review of the current literature has confirmed that dilated cardiomyopathy due to thrombotic microangiopathy is a rare manifestation of APS.
血栓性微血管病所致扩张型心肌病作为抗磷脂综合征（APS）的一种临床表现鲜有报道。我们描述了一例39岁患有系统性红斑狼疮（SLE）且抗磷脂抗体（aPL）呈阳性的女性患者，她出现了端坐呼吸和外周水肿。诊断为心肌血栓性微血管病所致扩张型心肌病，抗凝治疗防止了临床病情恶化。有趣的是，与其他病例不同，我们的患者未表现出APS的心脏外体征。对当前文献的回顾证实，血栓性微血管病所致扩张型心肌病是APS的一种罕见表现。
