小干扰RNA和微小RNA的加工：卡哈尔体的新功能
siRNA and miRNA processing: new functions for Cajal bodies.
作者信息
Pontes Olga, Pikaard Craig S
机构信息
Biology Department, Washington University, 1 Brookings Drive, St. Louis, MO 63130, USA.
出版信息
Curr Opin Genet Dev. 2008 Apr;18(2):197-203. doi: 10.1016/j.gde.2008.01.008. Epub 2008 Mar 11.
Abstract
In diverse eukaryotes, micro-RNAs (miRNAs) and small interfering RNAs (siRNAs) regulate important processes that include mRNA inactivation, viral defense, chromatin modification, and transposon silencing. Recently, nucleolus-associated Cajal bodies in plants have been implicated as sites of siRNA and miRNA biogenesis, whereas in animals siRNA and miRNA dicing occurs in the cytoplasm. The plant nucleolus also contains proteins of the nonsense-mediated mRNA decay pathway that in animals are found associated with cytoplasmic processing bodies (P-bodies). P-bodies also function in the degradation of mRNAs subjected to miRNA and siRNA targeting. Collectively, these observations suggest interesting variations in the way siRNAs and miRNAs can accomplish their similar functions in plants and animals.
摘要
在多种真核生物中，微小RNA（miRNA）和小干扰RNA（siRNA）调控着包括mRNA失活、病毒防御、染色质修饰和转座子沉默在内的重要过程。最近，植物中与核仁相关的卡哈尔体被认为是siRNA和miRNA生物合成的场所，而在动物中，siRNA和miRNA的切割发生在细胞质中。植物核仁还含有无义介导的mRNA降解途径的蛋白质，而在动物中，这些蛋白质与细胞质加工小体（P小体）相关。P小体也在受miRNA和siRNA靶向的mRNA降解中发挥作用。总的来说，这些观察结果表明，siRNA和miRNA在植物和动物中实现其相似功能的方式存在有趣的差异。
相似文献
1
siRNA and miRNA processing: new functions for Cajal bodies.小干扰RNA和微小RNA的加工：卡哈尔体的新功能
Curr Opin Genet Dev. 2008 Apr;18(2):197-203. doi: 10.1016/j.gde.2008.01.008. Epub 2008 Mar 11.
2
An ARGONAUTE4-containing nuclear processing center colocalized with Cajal bodies in Arabidopsis thaliana.一个含有AGO4的核加工中心与拟南芥中的 Cajal 体共定位。
Cell. 2006 Jul 14;126(1):93-106. doi: 10.1016/j.cell.2006.05.032.
3
Intersection of small RNA pathways in Arabidopsis thaliana sub-nuclear domains.拟南芥亚核域中小 RNA 通路的交汇
PLoS One. 2013 Jun 12;8(6):e65652. doi: 10.1371/journal.pone.0065652. Print 2013.
4
Post-transcriptional gene silencing by siRNAs and miRNAs.小干扰RNA和微小RNA介导的转录后基因沉默
Curr Opin Struct Biol. 2005 Jun;15(3):331-41. doi: 10.1016/j.sbi.2005.05.006.
5
Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants.在活体拟南芥植物中鉴定含有参与微小RNA生物合成蛋白质的细胞核切割体。
Curr Biol. 2007 May 1;17(9):818-23. doi: 10.1016/j.cub.2007.04.005. Epub 2007 Apr 19.
6
Synergistic interactions between Cajal bodies and the miRNA processing machinery.Cajal 体与 miRNA 加工机制之间的协同相互作用。
Mol Biol Cell. 2020 Jul 15;31(15):1561-1569. doi: 10.1091/mbc.E20-02-0144. Epub 2020 May 20.
7
Misregulation of AUXIN RESPONSE FACTOR 8 underlies the developmental abnormalities caused by three distinct viral silencing suppressors in Arabidopsis.AUXIN RESPONSE FACTOR 8 的失调是三种不同的病毒沉默抑制剂在拟南芥中引起发育异常的基础。
PLoS Pathog. 2011 May;7(5):e1002035. doi: 10.1371/journal.ppat.1002035. Epub 2011 May 12.
8
Loss of function of OsDCL1 affects microRNA accumulation and causes developmental defects in rice.水稻中OsDCL1功能丧失影响微小RNA积累并导致发育缺陷。
Plant Physiol. 2005 Sep;139(1):296-305. doi: 10.1104/pp.105.063420. Epub 2005 Aug 26.
9
Cell biology of the Arabidopsis nuclear siRNA pathway for RNA-directed chromatin modification.拟南芥用于RNA定向染色质修饰的核小干扰RNA途径的细胞生物学
Cold Spring Harb Symp Quant Biol. 2006;71:473-80. doi: 10.1101/sqb.2006.71.046.
10
Ectopic DICER-LIKE1 expression in P1/HC-Pro Arabidopsis rescues phenotypic anomalies but not defects in microRNA and silencing pathways.在P1/HC-Pro拟南芥中异位表达DICER-LIKE1可挽救表型异常，但不能挽救微小RNA和沉默途径中的缺陷。
Plant Cell. 2005 Nov;17(11):2873-85. doi: 10.1105/tpc.105.036608. Epub 2005 Oct 7.
引用本文的文献
1
A GFP splicing reporter in a coilin mutant background reveals links between alternative splicing, siRNAs, and coilin function in Arabidopsis thaliana.在 coilin 突变背景下的 GFP 剪接报告揭示了拟南芥中可变剪接、siRNAs 和 coilin 功能之间的联系。
G3 (Bethesda). 2023 Sep 30;13(10). doi: 10.1093/g3journal/jkad175.
2
Cajal bodies: Evolutionarily conserved nuclear biomolecular condensates with properties unique to plants.卡哈尔体：具有植物特有性质的进化上保守的核生物分子凝聚物。
Plant Cell. 2023 Sep 1;35(9):3214-3235. doi: 10.1093/plcell/koad140.
3
Nuclear dynamics: Formation of bodies and trafficking in plant nuclei.核动力学：植物细胞核中 bodies 的形成与运输
Front Plant Sci. 2022 Aug 23;13:984163. doi: 10.3389/fpls.2022.984163. eCollection 2022.
4
Targets and Mechanisms of Geminivirus Silencing Suppressor Protein AC2.双生病毒沉默抑制蛋白AC2的作用靶点与机制
Front Microbiol. 2021 Apr 9;12:645419. doi: 10.3389/fmicb.2021.645419. eCollection 2021.
5
Bidirectional differentiation of BMSCs induced by a biomimetic procallus based on a gelatin-reduced graphene oxide reinforced hydrogel for rapid bone regeneration.基于明胶-还原氧化石墨烯增强水凝胶的仿生骨痂诱导骨髓间充质干细胞双向分化以实现快速骨再生
Bioact Mater. 2020 Dec 31;6(7):2011-2028. doi: 10.1016/j.bioactmat.2020.12.003. eCollection 2021 Jul.
6
Tidying-up the plant nuclear space: domains, functions, and dynamics.整理植物细胞核空间：结构域、功能及动态变化
J Exp Bot. 2020 Aug 17;71(17):5160-5178. doi: 10.1093/jxb/eraa282.
7
Manipulation of the Plant Host by the Geminivirus AC2/C2 Protein, a Central Player in the Infection Cycle.双生病毒AC2/C2蛋白对植物宿主的操控，感染周期中的核心角色
Front Plant Sci. 2020 May 19;11:591. doi: 10.3389/fpls.2020.00591. eCollection 2020.
8
Synergistic interactions between Cajal bodies and the miRNA processing machinery.Cajal 体与 miRNA 加工机制之间的协同相互作用。
Mol Biol Cell. 2020 Jul 15;31(15):1561-1569. doi: 10.1091/mbc.E20-02-0144. Epub 2020 May 20.
9
sRNA-FISH: versatile fluorescent in situ detection of small RNAs in plants.sRNA-FISH：植物中小 RNA 的通用荧光原位检测。
Plant J. 2019 Apr;98(2):359-369. doi: 10.1111/tpj.14210. Epub 2019 Feb 12.
10
The Multiple Functions of the Nucleolus in Plant Development, Disease and Stress Responses.核仁在植物发育、疾病和应激反应中的多重功能
Front Plant Sci. 2018 Feb 9;9:132. doi: 10.3389/fpls.2018.00132. eCollection 2018.
本文引用的文献
1
Specialization and evolution of endogenous small RNA pathways.内源性小RNA途径的特化与进化
Nat Rev Genet. 2007 Nov;8(11):884-96. doi: 10.1038/nrg2179.
2
Location of a possible miRNA processing site in SmD3/SmB nuclear bodies in Arabidopsis.拟南芥中SmD3/SmB核小体中一个可能的微小RNA加工位点的定位
Plant Cell Physiol. 2007 Sep;48(9):1243-53. doi: 10.1093/pcp/pcm099. Epub 2007 Aug 3.
3
Argonaute proteins: mediators of RNA silencing.AGO蛋白：RNA沉默的介导因子。
Mol Cell. 2007 Jun 8;26(5):611-23. doi: 10.1016/j.molcel.2007.05.001.
4
Transcription and RNA interference in the formation of heterochromatin.异染色质形成过程中的转录与RNA干扰
Nature. 2007 May 24;447(7143):399-406. doi: 10.1038/nature05914.
5
RNA-directed DNA methylation mediated by DRD1 and Pol IVb: a versatile pathway for transcriptional gene silencing in plants.由DRD1和Pol IVb介导的RNA指导的DNA甲基化：植物转录基因沉默的一种通用途径。
Biochim Biophys Acta. 2007 May-Jun;1769(5-6):358-74. doi: 10.1016/j.bbaexp.2007.03.001. Epub 2007 Mar 12.
6
Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants.在活体拟南芥植物中鉴定含有参与微小RNA生物合成蛋白质的细胞核切割体。
Curr Biol. 2007 May 1;17(9):818-23. doi: 10.1016/j.cub.2007.04.005. Epub 2007 Apr 19.
7
The role of GW/P-bodies in RNA processing and silencing.GW小体/加工小体在RNA加工和沉默中的作用。
J Cell Sci. 2007 Apr 15;120(Pt 8):1317-23. doi: 10.1242/jcs.03429.
8
Cell biology of the Arabidopsis nuclear siRNA pathway for RNA-directed chromatin modification.拟南芥用于RNA定向染色质修饰的核小干扰RNA途径的细胞生物学
Cold Spring Harb Symp Quant Biol. 2006;71:473-80. doi: 10.1101/sqb.2006.71.046.
9
Biogenesis and intranuclear trafficking of human box C/D and H/ACA RNPs.人盒C/D和H/ACA核糖核蛋白颗粒的生物发生及核内运输
Cold Spring Harb Symp Quant Biol. 2006;71:407-17. doi: 10.1101/sqb.2006.71.025.
10
The function of RNAi in plant development.RNA干扰在植物发育中的作用。
Cold Spring Harb Symp Quant Biol. 2006;71:165-70. doi: 10.1101/sqb.2006.71.030.
Zotero 插件