Mursu Jaakko, Nurmi Tarja, Tuomainen Tomi-Pekka, Salonen Jukka T, Pukkala Eero, Voutilainen Sari
Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland.
Int J Cancer. 2008 Aug 1;123(3):660-3. doi: 10.1002/ijc.23421.
Limited amount of evidence suggests that high intake of flavonoids could be associated with decreased risk of lung and colorectal cancer, but more studies are needed. In this prospective cohort study, we assessed the relation between the intakes of 26 flavonoids from 5 subclasses; flavonols, flavones, flavanones, flavan-3-ols and anthocyanidins, and the risk of lung, prostate and colorectal cancer. The study population consisted of 2,590 middle-aged eastern Finnish men of the prospective population-based Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study. The mean intake of flavonoids was 131.0 +/- 214.7 mg/day. During the mean follow-up time of 16.2 years, 62 lung, 138 prostate, and 55 colorectal cancers occurred. All lung cancer cases occurred among either current smokers (n = 50) or previous smokers (n = 12). After adjustment for age, examination years, body mass index, smoking status, pack-years of smoking, physical activity and intakes of alcohol, total fat, saturated fat, fiber, vitamin C and E, relative risk (RR) for lung cancer was 0.27 (95% CI: 0.11-0.66) for the highest quarter of total flavonoid intake as compared with the lowest quarter. Out of 5 flavonoid subclasses, flavonols and flavan-3-ols were associated with lung cancer, for the highest quarter of intake the RR were 0.29 (95% CI: 0.11-0.78) and 0.24 (95% CI: 0.09-0.64), respectively. No association between flavonoid intake and risk of prostate or colorectal cancer were found. We conclude that high intake of flavonoids is associated with decreased risk of lung cancer in middle-aged Finnish smoking men.
有限的证据表明，高黄酮摄入量可能与降低肺癌和结直肠癌风险相关，但仍需要更多研究。在这项前瞻性队列研究中，我们评估了来自5个亚类（黄酮醇、黄酮、黄烷酮、黄烷-3-醇和花青素）的26种黄酮摄入量与肺癌、前列腺癌和结直肠癌风险之间的关系。研究人群包括基于库奥皮奥缺血性心脏病危险因素（KIHD）前瞻性人群研究中的2590名芬兰东部中年男性。黄酮类化合物的平均摄入量为131.0±214.7毫克/天。在平均16.2年的随访期内，发生了62例肺癌、138例前列腺癌和55例结直肠癌。所有肺癌病例均发生在当前吸烟者（n = 50）或既往吸烟者（n = 12）中。在调整年龄、检查年份、体重指数、吸烟状况、吸烟包年数、体力活动以及酒精、总脂肪、饱和脂肪、纤维、维生素C和E的摄入量后，与最低四分位数相比，总黄酮摄入量最高四分位数的肺癌相对风险（RR）为0.27（95%CI：（0.11 - 0.66）。在5个黄酮亚类中，黄酮醇和黄烷-3-醇与肺癌相关，摄入量最高四分位数的RR分别为0.29（95%CI：0.11 - 0.78）和0.24（95%CI：0.09 - 0.64）。未发现黄酮摄入量与前列腺癌或结直肠癌风险之间存在关联。我们得出结论，高黄酮摄入量与芬兰中年吸烟男性肺癌风险降低相关。
