一幅秀丽隐杆线虫基因相互作用图谱逐渐清晰可见。

A Caenorhabditis elegans genetic-interaction map wiggles into view.

作者信息

Gunsalus Kristin C

机构信息

Center for Genomics and Systems Biology and Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA.

出版信息

J Biol. 2008;7(3):8. doi: 10.1186/jbiol70. Epub 2008 Mar 7.

DOI:10.1186/jbiol70

PMID:18341704

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2323036/

Abstract

Systematic mapping of genetic-interaction networks will provide an essential foundation for understanding complex genetic disorders, mechanisms of genetic buffering and principles of robustness and evolvability. A recent study of signaling pathways in Caenorhabditis elegans lays the next row of bricks in this foundation.

摘要

系统绘制遗传相互作用网络将为理解复杂遗传疾病、遗传缓冲机制以及稳健性和进化性原理提供重要基础。最近一项关于秀丽隐杆线虫信号通路的研究为这一基础添砖加瓦。