Salkever David S, Johnston Stephen, Karakus Mustafa C, Ialongo Nicholas S, Slade Eric P, Stuart Elizabeth A
Department of Public Policy, University of Maryland, Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, MD 21250, USA.
Adm Policy Ment Health. 2008 Jul;35(4):261-9. doi: 10.1007/s10488-008-0168-9. Epub 2008 Mar 15.
We consider the implementation, in a non-research setting, of a new prevention program that has previously been evaluated in a randomized trial. When the target population for the implementation is heterogeneous, the overall net benefits of the implementation may differ substantially from those reported in the economic evaluation of the randomized trial, and from those that would be realized if the program were implemented within a selected subgroup of the target population. This note illustrates a simple and practical approach to targeting that can combine risk-factor results from the literature with the overall cost-benefit results from the program's randomized trial to maximize the expected net benefit of implementing the program in a heterogeneous population.
我们考虑在非研究环境中实施一项先前已在随机试验中进行评估的新预防计划。当实施的目标人群具有异质性时,实施的总体净效益可能与随机试验的经济评估中报告的效益有很大差异,也与在目标人群的选定子组中实施该计划所实现的效益有很大差异。本说明阐述了一种简单实用的目标设定方法,该方法可将文献中的风险因素结果与该计划随机试验的总体成本效益结果相结合,以在异质人群中实施该计划时使预期净效益最大化。