Mosaed Sameh, Chamberlain Winston Douglas, Liu John H K, Medeiros Felipe A, Weinreb Robert N
Department of Ophthalmology, University of California, Irvine, USA.
J Glaucoma. 2008 Mar;17(2):85-8. doi: 10.1097/IJG.0b013e31814b9922.
To evaluate the association between office-hour central corneal thickness (CCT) and 24-hour intraocular pressure (IOP) fluctuation in patients with glaucoma.
Observational case-control study.
Measurements of IOP were obtained every 2 hours during a 24-hour period from 52 untreated glaucoma patients and 29 age-matched normal control subjects housed in a sleep laboratory. Habitual IOP measurements were obtained using a pneumatonometer in the sitting positions during the diurnal/wake period (7 AM to 11 PM) and in the supine position during the nocturnal/sleep period (11 PM to 7 AM). CCT was measured in all subjects using ultrasound pachymetry once during office hours. The association between IOP fluctuation (peak IOP-trough IOP) during the 24-hour period and the office-hour CCT was assessed in both glaucoma patients and healthy age-matched controls using Spearman rank order correlation.
There was no statistically significant correlation between IOP fluctuation and CCT in glaucomatous (P=0.405) and normal subjects (P=0.456).
Twenty-four-hour IOP fluctuations were not correlated with single CCT measurements taken during office hours in glaucoma patients.
评估青光眼患者办公时间中央角膜厚度（CCT）与24小时眼压（IOP）波动之间的关联。
观察性病例对照研究。
在睡眠实验室对52例未经治疗的青光眼患者和29例年龄匹配的正常对照者进行24小时眼压测量，每2小时测量一次。日间/清醒期（上午7点至晚上11点）坐位时和夜间/睡眠期（晚上11点至上午7点）仰卧位时使用眼压计测量习惯性眼压。所有受试者在办公时间使用超声测厚法测量一次CCT。采用Spearman等级相关分析评估青光眼患者和年龄匹配的健康对照者24小时眼压波动（最高眼压-最低眼压）与办公时间CCT之间的关联。
青光眼患者（P = 0.405）和正常受试者（P = 0.456）的眼压波动与CCT之间无统计学显著相关性。
青光眼患者24小时眼压波动与办公时间单次CCT测量值无关。
