Hrnciarikova Dana, Juraskova Bozena, Hyspler Radomir, Solichova Dagmar, Ticha Alena, Klemera Petr, Hronek Miloslav, Zadak Zdenek
Department of Gerontology and Metabolic Care, Faculty Hospital, Hradec Kralove, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007 Dec;151(2):273-6. doi: 10.5507/bp.2007.046.
We are currently witnessing changes in views on the evaluation of serum proteins. A decrease may signal not only malnutrition. It may also be an indicator of simultaneously occurring inflammatory disease. Prealbumin, due to its short half-life, is a suitable indicator of changes in protein-energy balance, but its levels show, as with other serum proteins, a decrease in the case of inflammation too. The present study aimed to determine the prealbumin values of hospitalized geriatric patients and how they are affected by inflammatory disease.
In 101 patients aged over 80 years, the relationships were compared between prealbumin and C-reactive protein in the whole group and then in the subgroups with normal and increased C-reactive protein.
In 67.33 % of hospitalized geriatric patients prealbumin was below the limit of the norm. A statistically highly significant dependence (p < 0.001) was demonstrated between a decrease in prealbumin and an increase in C-reactive protein in the whole group. In the subgroup with normal C-reactive protein, no statistically significant decrease in prealbumin was demonstrated, whereas in the subgroup with increased C-reactive protein a significant decrease in prealbumin (p < 0.001 for the whole group, p < 0.01 men, p < 0.05 women) was found.
The study demonstrated subnormal mean initial values of prealbumin and a highly statistically significant negative correlation between a decrease in prealbumin and an increase in C-reactive protein in the whole group. We confirm that in inflammation there is a statistically significant decrease in serum concentration of prealbumin.
我们目前正目睹血清蛋白评估观点的变化。血清蛋白降低不仅可能表明营养不良，还可能是同时发生的炎症性疾病的一个指标。前白蛋白因其半衰期短，是蛋白质 - 能量平衡变化的合适指标，但与其他血清蛋白一样，在炎症情况下其水平也会降低。本研究旨在确定住院老年患者的前白蛋白值以及它们如何受到炎症性疾病的影响。
在101名80岁以上的患者中，比较了整个组以及C反应蛋白正常和升高的亚组中前白蛋白与C反应蛋白之间的关系。
在67.33%的住院老年患者中，前白蛋白低于正常范围。整个组中前白蛋白降低与C反应蛋白升高之间存在统计学上高度显著的相关性（p < 0.001）。在C反应蛋白正常的亚组中，未显示前白蛋白有统计学上显著的降低，而在C反应蛋白升高的亚组中，发现前白蛋白有显著降低（整个组p < 0.001，男性p < 0.01，女性p < 0.05）。
该研究表明前白蛋白的平均初始值低于正常，且整个组中前白蛋白降低与C反应蛋白升高之间存在统计学上高度显著的负相关。我们证实，在炎症情况下，血清前白蛋白浓度有统计学上显著的降低。
