Gökçay F, Oder G, Celebisoy N, Gökçay A, Sirin H, Kabasakal Y
Department of Neurology, Ege University Medical School, Bornova, Izmir, Turkey.
Acta Neurol Scand. 2008 Sep;118(3):189-92. doi: 10.1111/j.1600-0404.2008.00997.x. Epub 2008 Mar 18.
To determine the prevalence of headache in patients with primary Sjögren's syndrome (pSS) and to examine the relationship between headache types and clinical, serologic features of the disease.
The study enclosed 133 patients with the diagnoses of pSS and 97 healthy controls. A questionnaire designed to assess the presence of headache and if present to classify it according to the criteria of the International Headache Society was used.
In 133 of the pSS patients evaluated, 104 had headache. No association was present between types of headache and the clinical and laboratory manifestations of the disease. Both migraine and tension-type headache were more common in patients with pSS when compared with healthy controls (P < 0.001).
The high prevalence of migraine in pSS patients might be explained by a vascular headache triggered by immuno-mediated disease activity without an obvious clinic or laboratory marker.
确定原发性干燥综合征（pSS）患者中头痛的患病率，并研究头痛类型与该疾病临床、血清学特征之间的关系。
该研究纳入了133例诊断为pSS的患者和97例健康对照者。使用了一份旨在评估头痛是否存在以及若存在则根据国际头痛协会标准对其进行分类的问卷。
在评估的133例pSS患者中，104例有头痛。头痛类型与该疾病的临床和实验室表现之间无关联。与健康对照者相比，pSS患者中偏头痛和紧张型头痛均更为常见（P<0.001）。
pSS患者中偏头痛的高患病率可能是由免疫介导的疾病活动引发的血管性头痛所解释，且无明显的临床或实验室标志物。
