Shi Xuetao, Wang Yingjun, Wei Kun, Ren Li, Lai Chen
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
J Mater Sci Mater Med. 2008 Aug;19(8):2933-40. doi: 10.1007/s10856-008-3424-3. Epub 2008 Mar 25.
A novel material hexagonal mesoporous silica-hydroxyapatite (HMS-HA) has been developed based on self-assembly of nanohydroxyapatite in mesoporous silica in situ. The structural and textural properties of the materials are, respectively, characterized via X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), N(2) adsorption, thermogravimetic analysis, and high-resolution transmission electron spectroscopy (HRTEM). Variable crystallinity of HA involved in the mesopores yields from different sintering temperature, and correspondingly determines different degradation manners. This biocompatible new material hybridized nanoporosity to well acknowledge biofunctional scaffold (HA). It promises a high potential for application in drug and gene delivery.
一种新型材料六方介孔二氧化硅-羟基磷灰石（HMS-HA）已基于纳米羟基磷灰石在介孔二氧化硅中原位自组装而开发出来。通过X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）、N₂吸附、热重分析和高分辨率透射电子光谱（HRTEM）分别对材料的结构和织构性质进行了表征。介孔中HA的可变结晶度源于不同的烧结温度，并相应地决定了不同的降解方式。这种具有生物相容性的新材料将纳米孔隙率与良好的生物功能支架（HA）相结合。它在药物和基因递送应用方面具有很高的潜力。
