T细胞稳态
T cell homeostasis.
作者信息
Sprent Jonathan, Cho Jae-Ho, Boyman Onur, Surh Charles D
机构信息
Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
出版信息
Immunol Cell Biol. 2008 May-Jun;86(4):312-9. doi: 10.1038/icb.2008.12. Epub 2008 Mar 25.
The pool of mature T cells comprises a heterogeneous mixture of naive and memory CD4(+) and CD8(+) cells. These cells are long lived at a population level but differ markedly in their relative rates of turnover and survival. Here, we review how contact with exogenous stimuli, notably self MHC ligands and various gamma(c) cytokines, plays a decisive role in controlling normal T cell homeostasis.
成熟T细胞库由初始和记忆性CD4(+)及CD8(+)细胞的异质混合物组成。这些细胞在群体水平上寿命较长，但在其相对的更新率和存活率方面存在显著差异。在此，我们综述了与外源性刺激（尤其是自身MHC配体和各种γ(c)细胞因子）的接触如何在控制正常T细胞稳态中发挥决定性作用。
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