Lope Virginia, Pérez-Gómez Beatriz, Aragonés Nuria, López-Abente Gonzalo, Gustavsson Per, Plato Nils, Silva-Mato Agustín, Pollán Marina
CIBER Epidemiología y Salud Pública, Madrid, Spain.
Int Arch Occup Environ Health. 2009 Jan;82(2):267-74. doi: 10.1007/s00420-008-0314-4. Epub 2008 Mar 26.
To explore thyroid cancer (TC) risk in the Swedish population, associated with occupational exposure to certain chemicals.
National cancer and death registries were used to follow-up (1971-1989) all Swedish workers employed in the 1970 census. Each combination of occupation and industry was linked to a Swedish job-exposure matrix (JEM), with exposure to 13 chemicals classified as "possible exposure", "probable exposure" or "unexposed". Relative risks were obtained using Poisson models adjusted for age, period and geographical area. A second analysis was performed, in which adjustment was additionally made for simultaneous exposure to other matrix chemicals and ionising radiations.
Probable exposure to solvents among women displayed an increased risk (RR = 1.91; 95%CI:1.05-3.45), mainly due to a higher risk observed among shoe-cutters, lasters and sewers engaged in shoe-making.
Exposure to solvents, used mainly in the shoe and leather industry, seems to be associated with excess TC among women.
探讨瑞典人群中与职业接触某些化学物质相关的甲状腺癌（TC）风险。
利用国家癌症和死亡登记处对1970年人口普查中受雇的所有瑞典工人进行随访（1971 - 1989年）。职业和行业的每种组合都与瑞典工作接触矩阵（JEM）相关联，接触13种化学物质被分类为“可能接触”、“很可能接触”或“未接触”。使用针对年龄、时期和地理区域进行调整的泊松模型获得相对风险。进行了第二项分析，其中还对同时接触其他矩阵化学物质和电离辐射进行了调整。
女性中很可能接触溶剂显示出风险增加（RR = 1.91；95%CI：1.05 - 3.45），主要是由于在从事制鞋的裁鞋工、绷帮工和缝纫工中观察到较高风险。
主要用于鞋类和皮革行业的溶剂接触似乎与女性甲状腺癌超标有关。
