Chrysohoou Christina, Panagiotakos Demosthenes B, Pitsavos Christos, Skoumas John, Krinos Xenofon, Chloptsios Yannis, Nikolaou Vassilios, Stefanadis Christodoulos
First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
Am J Clin Nutr. 2007 May;85(5):1385-91. doi: 10.1093/ajcn/85.5.1385.
Dietary habits have long been associated with many manifestations of cardiovascular disease.
We sought to investigate whether a diet enriched with fish and n-3 fatty acid consumption are associated with changes in the potential duration of the electrical action, as represented by the QT duration on a resting electrocardiogram, in a population-based sample of Greek adults.
During 2001 and 2002, we randomly enrolled 1514 men (18-87 y old) and 1528 women (18-89 y old) stratified by age and sex distribution (in the 2001 Greek census) from the Attica area, Greece. We studied several demographic, anthropometric, lifestyle, dietary, and bioclinical factors of the participants. Dietary habits (including fish consumption) were evaluated by using a validated food-frequency questionnaire. All subjects underwent electrocardiography with a 12-lead surface, in which, along with several other indexes, QT duration was measured, and the heart rate-corrected QT (QTc) was calculated (corrected by using Bazett's rate). The tested hypothesis was evaluated through multiple linear regression analysis, after control for physical activity status, sex, age, medication intake, and several other potential confounders.
Compared with fish nonconsumers, those who consumed >300 g fish/wk had a mean 13.6% lower QTc (P<0.01). These findings were confirmed after adjustment for age, sex, physical activity status, BMI, smoking habits, intake of nuts, and other confounders. Moreover, compared with fish nonconsumers, those who consumed >or=300 g fish/wk had a 29.2% lower likelihood of having QTc intervals >0.45 s (P=0.03).
Long-term consumption of fish is associated with lower QTc interval in free-eating people without any evidence of cardiovascular disease. Thus, fish intake seems to provide antiarrhythmic protection at a population level.
饮食习惯长期以来一直与心血管疾病的多种表现相关。
我们试图在以希腊成年人为基础的样本中，研究富含鱼类和摄入n-3脂肪酸的饮食是否与静息心电图上QT间期所代表的电活动潜在持续时间的变化有关。
在2001年和2002年期间，我们从希腊阿提卡地区按照年龄和性别分布（根据2001年希腊人口普查数据）随机招募了1514名男性（18 - 87岁）和1528名女性（18 - 89岁）。我们研究了参与者的多种人口统计学、人体测量学、生活方式、饮食和生物临床因素。饮食习惯（包括鱼类消费情况）通过使用经过验证的食物频率问卷进行评估。所有受试者均接受12导联体表心电图检查，除了其他几个指标外，还测量了QT间期，并计算心率校正后的QT（QTc）（使用Bazett公式校正心率）。在控制了身体活动状况、性别、年龄、药物摄入以及其他几个潜在混杂因素后，通过多元线性回归分析对所检验的假设进行评估。
与不食用鱼类者相比，每周食用鱼类超过300克的人其QTc平均降低13.6%（P<0.01）。在对年龄、性别、身体活动状况、体重指数、吸烟习惯、坚果摄入量和其他混杂因素进行校正后，这些发现得到了证实。此外，与不食用鱼类者相比，每周食用鱼类≥300克的人QTc间期>0.45秒的可能性降低29.2%（P = 0.03）。
在无任何心血管疾病证据的自由饮食人群中，长期食用鱼类与较低的QTc间期相关。因此，鱼类摄入似乎在人群层面提供了抗心律失常保护作用。
