Nyström M, Peräsalo J, Salaspuro M
Finnish Student Health Service, Helsinki.
Alcohol Clin Exp Res. 1991 Oct;15(5):877-80. doi: 10.1111/j.1530-0277.1991.tb00617.x.
In a sample of 203 first-year university students, serum beta-hexosaminidase (beta-HEX) was studied as a possible marker of heavy drinking. There are no previous studies on beta-HEX in a young nonalcoholic population. All students were healthy and without regular medication except the use of p-pills in 49 of the 123 female students. Alcohol consumption was measured on a frequency-volume scale. Serum beta-HEX did not correlate with reported drinking, gamma-glutamyl transferase (GGT), mean corpuscular volume (MCV) nor alcohol problems. The mean beta-HEX of 26 teetotalers did not differ from that of the heaviest drinking group (n = 25). A new finding was a significant (p = 0.009) increase of serum beta-HEX in female students using oral contraceptives. We conclude that serum beta-HEX is a poor indicator of alcohol consumption in young university students and if elevated the use of p-pills must be considered.
在203名大学一年级学生的样本中，研究了血清β-己糖胺酶（β-HEX）作为重度饮酒可能标志物的情况。此前尚无关于年轻非酒精人群β-HEX的研究。所有学生均健康，除123名女生中有49人使用避孕药外，均无规律用药情况。通过频率-量度量表测量酒精摄入量。血清β-HEX与报告的饮酒量、γ-谷氨酰转移酶（GGT）、平均红细胞体积（MCV）以及酒精相关问题均无相关性。26名戒酒者的平均β-HEX与饮酒量最大组（n = 25）的平均β-HEX无差异。一项新发现是，使用口服避孕药的女学生血清β-HEX显著升高（p = 0.009）。我们得出结论，血清β-HEX在年轻大学生中并非酒精摄入量的良好指标，若其升高，必须考虑避孕药的使用情况。
