Lim Jin-Ho, Yang Seong-Ho, Xu Ye, Yoon San-Hyun, Chian Ri-Cheng
Maria Fertility Hospital, Seoul, South Korea.
Fertil Steril. 2009 Apr;91(4):1050-5. doi: 10.1016/j.fertnstert.2008.01.066. Epub 2008 Mar 25.
To determine a successful method of selecting patients for natural cycle IVF combined with in vitro maturation (IVM) of immature oocytes and to determine treatment efficacy.
Retrospective analysis of IVF treatments.
Hospital IVF clinic.
PATIENT(S): Women with infertility according to ovarian reserve and endocrine profile were selected for different treatments.
INTERVENTIONS(S): According to screening criteria, infertile women were divided into three treatments: [1] natural cycle IVF combined with IVM (IVF/M), [2] IVM alone, and [3] controlled ovarian hyperstimulation (COH) with gonadotropin.
MAIN OUTCOME MEASURE(S): The distribution of completed IVF-ET cycles in each treatment; clinical pregnancy and implantation rates in each treatment.
RESULT(S): A total of 417 cycles were started, and 410 cycles (98.3%) were completed. Of 410 cycles, 151 (36.8%) were treated by natural cycle IVF/M, 63 (15.4%) underwent IVM alone, and 196 (47.8%) underwent COH. With increasing age fewer cycles can be treated by natural cycle IVF/M or IVM. Clinical pregnancy rates were 40.4% (61 of 151) for natural cycle IVF/M, 41.3% (26 of 63) for IVM alone, and 37.8% (74 of 196) for COH. There were no differences in implantation rate in the three groups (17.8% [82 of 462], 16.7% [35 of 210], and 20.1% [103 of 513]).
CONCLUSION(S): Natural cycle IVF/M together with IVM-alone treatment can offer more than 50% of infertile women with an acceptable pregnancy and implantations rates.
确定一种成功的方法来选择适合自然周期体外受精（IVF）联合未成熟卵母细胞体外成熟（IVM）的患者，并确定治疗效果。
对IVF治疗进行回顾性分析。
医院IVF诊所。
根据卵巢储备和内分泌情况选择患有不孕症的女性进行不同治疗。
根据筛选标准，将不孕女性分为三种治疗方式：[1]自然周期IVF联合IVM（IVF/M），[2]单纯IVM，[3]使用促性腺激素进行控制性卵巢刺激（COH）。
每种治疗中完成的IVF-ET周期分布；每种治疗的临床妊娠率和着床率。
共启动417个周期，410个周期（98.3%）完成。在410个周期中，151个（36.8%）接受自然周期IVF/M治疗，63个（15.4%）单纯接受IVM治疗，196个（47.8%）接受COH治疗。随着年龄增长，自然周期IVF/M或IVM能治疗的周期数减少。自然周期IVF/M的临床妊娠率为40.4%（151例中的61例），单纯IVM为41.3%（63例中的26例），COH为37.8%（196例中的74例）。三组的着床率无差异（分别为17.8%[462例中的82例]、16.7%[210例中的35例]和20.1%[513例中的103例]）。
自然周期IVF/M联合单纯IVM治疗可为超过50%的不孕女性提供可接受的妊娠率和着床率。
